C11orf30 Antibody - #DF7645

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Product: C11orf30 Antibody
Catalog: DF7645
Description: Rabbit polyclonal antibody to C11orf30
Application: WB
Reactivity: Human
Prediction: Pig, Bovine, Horse, Sheep, Dog
Mol.Wt.: 150 kDa; 141kD(Calculated).
Uniprot: Q7Z589
RRID: AB_2841124

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Prediction:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Dog(100%)
Clonality:
Polyclonal
Specificity:
C11orf30 Antibody detects endogenous levels of total C11orf30.
RRID:
AB_2841124
Cite Format: Affinity Biosciences Cat# DF7645, RRID:AB_2841124.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

C11orf30; Chromosome 11 open reading frame 30; Emsy; EMSY protein; EMSY_HUMAN; FLJ90741; GL002; Protein EMSY;

Immunogens

Immunogen:
Uniprot:

Q7Z589(EMSY_HUMAN) >>Visit HPA database.

Gene(ID):
EMSY(56946)
Sequence:
MPVVWPTLLDLSRDECKRILRKLELEAYAGVISALRAQGDLTKEKKDLLGELSKVLSISTERHRAEVRRAVNDERLTTIAHNMSGPNSSSEWSIEGRRLVPLMPRLVPQTAFTVTANAVANAAIQHNASLPVPAETGSKEVVCYSYTSTTSTPTSTPVPSGSIATVKSPRPASPASNVVVLPSGSTVYVKSVSCSDEDEKPRKRRRTNSSSSSPVVLKEVPKAVVPVSKTITVPVSGSPKMSNIMQSIANSLPPHMSPVKITFTKPSTQTTNTTTQKVIIVTTSPSSTFVPNILSKSHNYAAVTKLVPTSVIASTTQKPPVVITASQSSLVSNSSSGSSSSTPSPIPNTVAVTAVVSSTPSVVMSTVAQGVSTSAIKMASTRLPSPKSLVSAPTQILAQFPKQHQQSPKQQLYQVQQQTQQQVAQPSPVSHQQQPQQSPLPPGIKPTIQIKQESGVKIITQQVQPSKILPKPVTATLPTSSNSPIMVVSSNGAIMTTKLVTTPTGTQATYTRPTVSPSIGRMAATPGAATYVKTTSGSIITVVPKSLATLGGKIISSNIVSGTTTKITTIPMTSKPNVIVVQKTTGKGTTIQGLPGKNVVTTLLNAGGEKTIQTVPTGAKPAILTATRPITKMIVTQPKGIGSTVQPAAKIIPTKIVYGQQGKTQVLIKPKPVTFQATVVSEQTRQLVTETLQQASRVAEAGNSSIQEGKEEPQNYTDSSSSSTESSQSSQDSQPVVHVIASRRQDWSEHEIAMETSPTIIYQDVSSESQSATSTIKALLELQQTTVKEKLESKPRQPTIDLSQMAVPIQMTQEKRHSPESPSIAVVESELVAEYITTERTDEGTEVAFPLLVSHRSQPQQPSQPQRTLLQHVAQSQTATQTSVVVKSIPASSPGAITHIMQQALSSHTAFTKHSEELGTEEGEVEEMDTLDPQTGLFYRSALTQSQSAKQQKLSQPPLEQTQLQVKTLQCFQTKQKQTIHLQADQLQHKLPQMPQLSIRHQKLTPLQQEQAQPKPDVQHTQHPMVAKDRQLPTLMAQPPQTVVQVLAVKTTQQLPKLQQAPNQPKIYVQPQTPQSQMSLPASSEKQTASQVEQPIITQGSSVTKITFEGRQPPTVTKITGGSSVPKLTSPVTSISPIQASEKTAVSDILKMSLMEAQIDTNVEHMIVDPPKKALATSMLTGEAGSLPSTHMVVAGMANSTPQQQKCRESCSSPSTVGSSLTTRKIDPPAVPATGQFMRIQNVGQKKAEESPAEIIIQAIPQYAIPCHSSSNVVVEPSGLLELNNFTSQQLDDEETAMEQDIDSSTEDGTEPSPSQSSAERS

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Xenopus
57
Zebrafish
0
Chicken
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q7Z589 As Substrate

Site PTM Type Enzyme
T7 Phosphorylation
Y28 Phosphorylation
S168 Phosphorylation
S173 Phosphorylation
S176 Phosphorylation
Y188 Phosphorylation
S193 Phosphorylation
S195 Phosphorylation
T207 Phosphorylation
S209 Phosphorylation P31749 (AKT1)
S210 Phosphorylation
S211 Phosphorylation
S212 Phosphorylation
S213 Phosphorylation
S228 O-Glycosylation
K229 Ubiquitination
S236 O-Glycosylation
S238 Phosphorylation
S257 Phosphorylation
T262 Phosphorylation
T271 O-Glycosylation
T273 Phosphorylation
T274 Phosphorylation
S287 Phosphorylation
K296 Ubiquitination
Y300 Phosphorylation
S385 Phosphorylation
K387 Ubiquitination
K402 Ubiquitination
K451 Sumoylation
S466 Phosphorylation
T501 O-Glycosylation
T502 Phosphorylation
T504 Phosphorylation
T506 O-Glycosylation
T511 Phosphorylation
T530 Phosphorylation
Y531 Phosphorylation
T534 O-Glycosylation
T535 O-Glycosylation
T541 Phosphorylation
S546 Phosphorylation
K553 Ubiquitination
S557 O-Glycosylation
T565 Phosphorylation
T568 Phosphorylation
T569 Phosphorylation
K575 Ubiquitination
K583 Ubiquitination
K587 Ubiquitination
K597 Ubiquitination
K610 Ubiquitination
K620 Acetylation
K620 Ubiquitination
K639 Sumoylation
K639 Ubiquitination
S643 Phosphorylation
K650 Ubiquitination
K655 Ubiquitination
K663 Ubiquitination
K669 Ubiquitination
S705 Phosphorylation
K710 Sumoylation
K710 Ubiquitination
Y762 Phosphorylation
K788 Ubiquitination
S793 Phosphorylation
T799 Phosphorylation
K815 Ubiquitination
S818 Phosphorylation
S823 Phosphorylation
S876 Phosphorylation
S893 Phosphorylation
S946 Phosphorylation
K950 Ubiquitination
K953 Ubiquitination
K967 Ubiquitination
K975 Ubiquitination
K977 Ubiquitination
K990 Ubiquitination
K1003 Ubiquitination
K1015 Sumoylation
K1015 Ubiquitination
K1028 Ubiquitination
K1066 Ubiquitination
T1073 Phosphorylation
S1079 Phosphorylation
T1120 O-Glycosylation
T1129 Phosphorylation
S1130 Phosphorylation
S1134 Phosphorylation
S1136 Phosphorylation
S1141 Phosphorylation
K1143 Ubiquitination
S1200 Phosphorylation
T1201 Phosphorylation
S1210 Phosphorylation
S1212 Phosphorylation
S1213 Phosphorylation
T1216 Phosphorylation
S1219 Phosphorylation
T1223 Phosphorylation

Research Backgrounds

Function:

Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors.

PTMs:

O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the phosphorylation status.

Subcellular Location:

Nucleus.
Note: Localizes to DNA damage markers in irradiated cells, suggesting that it participates in DNA repair process.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Homodimer. Interacts with the transactivation domain of BRCA2. Interacts with the chromoshadow domain of CBX1 and with ZMYND11. Does not interact with CBX3 or CBX5. Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity. Interacts with ZMYND11.

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