Calponin Antibody - #DF7671
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF7671, RRID:AB_2841143.
Fold/Unfold
Basic calponin; Calponin 1; Calponin 1 basic smooth muscle; Calponin H1; Calponin H1 smooth muscle; Calponin-1; Calponin1; Calponins basic; CNN 1; Cnn1; CNN1_HUMAN; Epididymis secretory protein Li 14; HEL S 14; Sm Calp; SMCC; smooth muscle;
Immunogens
- P51911 CNN1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSSAHFNRGPAYGLSAEVKNKLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELGEPAHNHHAHNYYNSA
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P51911 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Phosphorylation | Uniprot | |
| S3 | Phosphorylation | Uniprot | |
| Y12 | Phosphorylation | Uniprot | |
| Y26 | Phosphorylation | Uniprot | |
| T170 | Phosphorylation | O75116 (ROCK2) | Uniprot |
| S175 | Phosphorylation | O75116 (ROCK2) | Uniprot |
| T180 | Phosphorylation | O75116 (ROCK2) | Uniprot |
| Y182 | Phosphorylation | Uniprot | |
| T184 | Phosphorylation | O75116 (ROCK2) | Uniprot |
| Y189 | Phosphorylation | Uniprot | |
| T210 | Phosphorylation | Uniprot | |
| S215 | Phosphorylation | Uniprot | |
| K225 | Acetylation | Uniprot | |
| T259 | Phosphorylation | O75116 (ROCK2) | Uniprot |
| Y261 | Phosphorylation | Uniprot | |
| Y278 | Phosphorylation | Uniprot | |
| Y293 | Phosphorylation | Uniprot | |
| Y294 | Phosphorylation | Uniprot |
Research Backgrounds
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity).
Smooth muscle, and tissues containing significant amounts of smooth muscle.
Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1.
Belongs to the calponin family.
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