MMP21 Antibody - #DF7695
| Product: | MMP21 Antibody |
| Catalog: | DF7695 |
| Description: | Rabbit polyclonal antibody to MMP21 |
| Application: | WB |
| Reactivity: | Human, Mouse, Monkey |
| Prediction: | Rabbit, Dog |
| Mol.Wt.: | 65 kDa; 65kD(Calculated). |
| Uniprot: | Q8N119 |
| RRID: | AB_2841166 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF7695, RRID:AB_2841166.
Fold/Unfold
Matrix metalloproteinase 21; MIFR; MMP 21;
Immunogens
Identified in fetal brain, kidney and liver. In adult tissues found primarily in ovary, kidney, liver, lung, placenta, brain and peripheral blood leukocytes. Expressed as well in various cancer cell lines.
- Q8N119 MMP21_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLAASIFRPTLLLCWLAAPWPTQPESLFHSRDRSDLEPSPLRQAKPIADLHAAQRFLSRYGWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWRLGDIHFDDDEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQEPAFELDWSDRKAIQKLYGSCEGSFDTAFDWIRKERNQYGEVMVRFSTYFFRNSWYWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKSYPKLISEGFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFPAVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVNDKDKQQNSWLPANGLFPKKFISEKWFDVCDVHISTLNM
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8N119 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S39 | Phosphorylation | Uniprot | |
| T79 | Phosphorylation | Uniprot | |
| S206 | Phosphorylation | Uniprot | |
| T209 | Phosphorylation | Uniprot | |
| Y347 | Phosphorylation | Uniprot | |
| K438 | Acetylation | Uniprot | |
| S469 | Phosphorylation | Uniprot | |
| S539 | Phosphorylation | Uniprot | |
| S553 | Phosphorylation | Uniprot | |
| S565 | Phosphorylation | Uniprot | |
| T566 | Phosphorylation | Uniprot |
Research Backgrounds
Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway. Cleaves alpha-1-antitrypsin.
The precursor is cleaved by a furin endopeptidase.
Secreted.
Identified in fetal brain, kidney and liver. In adult tissues found primarily in ovary, kidney, liver, lung, placenta, brain and peripheral blood leukocytes. Expressed as well in various cancer cell lines.
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Belongs to the peptidase M10A family.
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