CAPNS1 Antibody - #DF7871
| Product: | CAPNS1 Antibody |
| Catalog: | DF7871 |
| Description: | Rabbit polyclonal antibody to CAPNS1 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 28 kDa; 28kD(Calculated). |
| Uniprot: | P04632 |
| RRID: | AB_2841300 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF7871, RRID:AB_2841300.
Fold/Unfold
30K; Calcium activated neutral proteinase; Calcium activated neutral proteinase small subunit; Calcium dependent protease small subunit 1; Calcium dependent protease small subunit; Calcium-activated neutral proteinase small subunit; Calcium-dependent protease small subunit 1; Calcium-dependent protease small subunit; Calpain 4; Calpain 4 small subunit (30K); Calpain 4 small subunit; Calpain regulatory subunit; Calpain small polypeptide; Calpain small subunit 1; Calpain4; CalpainS1; CANP; CANP small subunit; CANPS; CAPN 4; CAPN S1; CAPN4; CAPNS 1; CAPNS; Capns1; CDPS; CPNS1_HUMAN; CSS 1; CSS1;
Immunogens
- P04632 CPNS1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGGGTAMRILGGVISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P04632 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S6 | Phosphorylation | Uniprot | |
| K9 | Acetylation | Uniprot | |
| K9 | Methylation | Uniprot | |
| K9 | Sumoylation | Uniprot | |
| S34 | Phosphorylation | Uniprot | |
| S67 | Phosphorylation | Uniprot | |
| S70 | Phosphorylation | Uniprot | |
| T85 | Phosphorylation | Uniprot | |
| Y87 | Phosphorylation | Uniprot | |
| S88 | Phosphorylation | Uniprot | |
| R99 | Methylation | Uniprot | |
| K126 | Ubiquitination | Uniprot | |
| K135 | Ubiquitination | Uniprot | |
| C144 | S-Nitrosylation | Uniprot | |
| S146 | Phosphorylation | Uniprot | |
| S153 | Phosphorylation | Uniprot | |
| T156 | Phosphorylation | Uniprot | |
| K158 | Ubiquitination | Uniprot | |
| K165 | Ubiquitination | Uniprot | |
| K172 | Ubiquitination | Uniprot | |
| Y178 | Phosphorylation | Uniprot | |
| K179 | Acetylation | Uniprot | |
| K179 | Ubiquitination | Uniprot | |
| S218 | Phosphorylation | Uniprot |
Research Backgrounds
Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
Cytoplasm. Cell membrane.
Note: Translocates to the plasma membrane upon calcium binding.
Homodimer or heterodimer of a large (catalytic) and a small (regulatory) subunit. In presence of calcium, the heterodimer dissociates (By similarity).
The contact of the 5th EF-hand domain from each monomer allows the formation of the homodimer and also appears to mediate the contact between the large catalytic subunit and small regulatory subunit for the formation of the heterodimer.
EF-hand domains are paired. EF-hand 1 is paired with EF-hand 2 and EF-hand 3 is paired with EF-hand 4. The fifth EF-hand domain, left unpaired, does not bind the calcium but is responsible of the dimerization by EF-embrace. The first four EF-hand domains bind calcium, however it is not sure if the binding of EF-hand 4 to calcium is physiologically relevant.
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