C17orf37 Antibody - #DF7920
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF7920, RRID:AB_2841334.
Fold/Unfold
C17orf37; C17orf37 homolog; C35; chromosome 17 open reading frame 37; HBV X transactivated gene 4 protein; HBV X-transactivated gene 4 protein; HBV XAg transactivated protein 4; HBV XAg-transactivated protein 4; MGC14832; Mien1; MIEN1_HUMAN; Migration and invasion enhancer 1; ORB3; Protein C17orf37; Protein C35; RDX12; Redox protein, 12-KD; XTP4;
Immunogens
Among normal tissues, present only in Leydig cells. Strongly up-regulated in breast cancers and in brain cancer distant metastasis (at protein level). Up-regulated in prostate cancer cells and in the higher grades of prostate adenocarcinoma (at protein level).
- Q9BRT3 MIEN1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSGEPGQTSVAPPPEEVEPGSGVRIVVEYCEPCGFEATYLELASAVKEQYPGIEIESRLGGTGAFEIEINGQLVFSKLENGGFPYEKDLIEAIRRASNGETLEKITNSRPPCVIL
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9BRT3 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| S2 | Phosphorylation | Uniprot | |
| Y39 | Phosphorylation | Uniprot | |
| Y50 | Phosphorylation | Uniprot | |
| K87 | Ubiquitination | Uniprot | |
| S97 | Phosphorylation | Uniprot |
Research Backgrounds
Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.
Isoprenylation facilitates association with the plasma membrane and enhances the migratory phenotype of cells by inducing increased filopodia formation.
Cytoplasm>Cytosol. Cell membrane>Lipid-anchor>Cytoplasmic side.
Note: Concentrates at the leading edge of migrating cells. Localizes outside membrane raft regions.
Among normal tissues, present only in Leydig cells. Strongly up-regulated in breast cancers and in brain cancer distant metastasis (at protein level). Up-regulated in prostate cancer cells and in the higher grades of prostate adenocarcinoma (at protein level).
Interacts with GPX1.
Belongs to the SelWTH family.
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