OLIG2 Antibody - #DF8004
| Product: | OLIG2 Antibody |
| Catalog: | DF8004 |
| Description: | Rabbit polyclonal antibody to OLIG2 |
| Application: | WB IHC |
| Reactivity: | Human, Monkey |
| Prediction: | Pig, Dog, Chicken, Xenopus |
| Mol.Wt.: | 32 kDa; 32kD(Calculated). |
| Uniprot: | Q13516 |
| RRID: | AB_2841383 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8004, RRID:AB_2841383.
Fold/Unfold
Basic domain helix loop helix protein class B 1; Basic helix loop helix protein class B 1; BHLHB; bHLHB1; bHLHe19; Class B basic helix loop helix protein 1; Class B basic helix-loop-helix protein 1; class E basic helix loop helix protein 19; Class E basic helix-loop-helix protein 19; Human protein kinase C binding protein RACK17; Olig2; OLIG2_HUMAN; Oligo2; Oligodendrocyte lineage transcription factor 2; Oligodendrocyte specific bHLH transcription factor 2; Oligodendrocyte transcription factor 2; OTTHUMP00000067569; OTTHUMP00000067570; PRKCBP2; Protein kinase C binding protein 2; Protein kinase C binding protein RACK17; Protein kinase C-binding protein 2; Protein kinase C-binding protein RACK17; RACK17;
Immunogens
Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.
- Q13516 OLIG2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDSDASLVSSRPSSPEPDDLFLPARSKGSSGSAFTGGTVSSSTPSDCPPELSAELRGAMGSAGAHPGDKLGGSGFKSSSSSTSSSTSSAAASSTKKDKKQMTEPELQQLRLKINSRERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLVSEIYGGHHAGFHPSACGGLAHSAPLPAATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAAAAAAVSSASLPGSGLPSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGASGGFQHWGGMPCPCSMCQVPPPHHHVSAMGAGSLPRLTSDAK
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q13516 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S10 | Phosphorylation | Uniprot | |
| S13 | Phosphorylation | Uniprot | |
| S14 | Phosphorylation | Uniprot | |
| S30 | Phosphorylation | Uniprot | |
| S32 | Phosphorylation | Uniprot | |
| T43 | Phosphorylation | Uniprot | |
| S61 | Phosphorylation | Uniprot | |
| S73 | Phosphorylation | Uniprot | |
| S77 | Phosphorylation | Uniprot | |
| S80 | Phosphorylation | Uniprot | |
| S83 | Phosphorylation | Uniprot | |
| S84 | Phosphorylation | Uniprot | |
| S85 | Phosphorylation | Uniprot | |
| T151 | Phosphorylation | Uniprot | |
| T163 | Phosphorylation | Uniprot | |
| S165 | Phosphorylation | Uniprot |
Research Backgrounds
Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Functions together with ZNF488 to promote oligodendrocyte differentiation. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.
Nucleus. Cytoplasm.
Note: The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2.
Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.
Interacts with NKX2-2. Interacts with ZNF488.
The bHLH is essential for interaction with NKX2-2.
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