UNC13D Antibody - #DF8158
| Product: | UNC13D Antibody |
| Catalog: | DF8158 |
| Description: | Rabbit polyclonal antibody to UNC13D |
| Application: | WB |
| Reactivity: | Human |
| Prediction: | Pig, Dog |
| Mol.Wt.: | 123 kDa; 123kD(Calculated). |
| Uniprot: | Q70J99 |
| RRID: | AB_2841483 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8158, RRID:AB_2841483.
Fold/Unfold
FHL 3; FHL3; FLJ00067; HLH 3; HLH3; HPLH 3; HPLH3; Jinx; Munc13 4; Munc13-4; Protein unc 13 homolog D; Protein unc-13 homolog D; UN13D_HUMAN; Unc 13 homolog D; UNC 13D; Unc-13 homolog D (C. elegans); Unc13 homolog D (C elegans); Unc13 homolog D; UNC13, C. elegans, homolog of, D; UNC13D; Unc13h4;
Immunogens
Expressed at high levels in spleen, thymus and leukocytes. Also expressed in lung and placenta, and at very low levels in brain, heart, skeletal muscle and kidney. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells.
- Q70J99 UN13D_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATLLSHPQQRPPFLRQAIKIRRRRVRDLQDPPPQMAPEIQPPSHHFSPEQRALLYEDALYTVLHRLGHPEPNHVTEASELLRYLQEAFHVEPEEHQQTLQRVRELEKPIFCLKATVKQAKGILGKDVSGFSDPYCLLGIEQGVGVPGGSPGSRHRQKAVVRHTIPEEETHRTQVITQTLNPVWDETFILEFEDITNASFHLDMWDLDTVESVRQKLGELTDLHGLRRIFKEARKDKGQDDFLGNVVLRLQDLRCREDQWYPLEPRTETYPDRGQCHLQFQLIHKRRATSASRSQPSYTVHLHLLQQLVSHEVTQHEAGSTSWDGSLSPQAATVLFLHATQKDLSDFHQSMAQWLAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQQEELAASFSSLLTYGLSLIRRFRSVFPLSVSDSPARLQSLLRVLVQMCKMKAFGELCPNTAPLPQLVTEALQTGTTEWFHLKQQHHQPMVQGIPEAGKALLGLVQDVIGDLHQCQRTWDKIFHNTLKIHLFSMAFRELQWLVAKRVQDHTTVVGDVVSPEMGESLFQLYISLKELCQLRMSSSERDGVLALDNFHRWFQPAIPSWLQKTYNEALARVQRAVQMDELVPLGELTKHSTSAVDLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSSGQKDQGQAANMLCVVVNDMEQLRLVIGKLPAQLAWEALEQRVGAVLEQGQLQNTLHAQLQSALAGLGHEIRTGVRTLAEQLEVGIAKHIQKLVGVRESVLPEDAILPLMKFLEVELCYMNTNLVQENFSSLLTLLWTHTLTVLVEAAASQRSSSLASNRLKIALQNLEICFHAEGCGLPPKALHTATFQALQRDLELQAASSRELIRKYFCSRIQQQAETTSEELGAVTVKASYRASEQKLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAARETQKHKKDLHPLFDETFEFLVPAEPCRKAGACLLLTVLDYDTLGADDLEGEAFLPLREVPGLSGSEEPGEVPQTRLPLTYPAPNGDPILQLLEGRKGDREAQVFVRLRRHRAKQASQHALRPAP
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q70J99 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y56 | Phosphorylation | Uniprot | |
| Y61 | Phosphorylation | Uniprot | |
| T62 | Phosphorylation | Uniprot | |
| K108 | Ubiquitination | Uniprot | |
| K126 | Ubiquitination | Uniprot | |
| Y135 | Phosphorylation | Uniprot | |
| S150 | Phosphorylation | Uniprot | |
| S153 | Phosphorylation | Uniprot | |
| K216 | Ubiquitination | Uniprot | |
| K237 | Ubiquitination | Uniprot | |
| K285 | Ubiquitination | Uniprot | |
| Y405 | Phosphorylation | Uniprot | |
| K473 | Ubiquitination | Uniprot | |
| K511 | Acetylation | Uniprot | |
| K511 | Ubiquitination | Uniprot | |
| T541 | Phosphorylation | Uniprot | |
| T542 | Phosphorylation | Uniprot | |
| S549 | Phosphorylation | Uniprot | |
| K599 | Ubiquitination | Uniprot | |
| K625 | Ubiquitination | Uniprot | |
| S629 | Phosphorylation | Uniprot | |
| K678 | Ubiquitination | Uniprot | |
| K689 | Ubiquitination | Uniprot | |
| K714 | Ubiquitination | Uniprot | |
| K773 | Ubiquitination | Uniprot | |
| K777 | Ubiquitination | Uniprot | |
| S784 | Phosphorylation | Uniprot | |
| K894 | Ubiquitination | Uniprot | |
| K917 | Ubiquitination | Uniprot | |
| K973 | Ubiquitination | Uniprot | |
| K1079 | Ubiquitination | Uniprot |
Research Backgrounds
Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.
Cytoplasm. Membrane>Peripheral membrane protein. Late endosome. Recycling endosome. Lysosome.
Note: Colocalizes with cytotoxic granules at the plasma membrane. Localizes to endosomal exocytic vesicles.
Expressed at high levels in spleen, thymus and leukocytes. Also expressed in lung and placenta, and at very low levels in brain, heart, skeletal muscle and kidney. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells.
Interacts with DOC2A (By similarity). Interacts with RAB27A.
The MHD1 and MHD2 domains mediate localization on recycling endosomes and lysosome.
Belongs to the unc-13 family.
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