ZBTB33 Antibody - #DF8183
| Product: | ZBTB33 Antibody |
| Catalog: | DF8183 |
| Description: | Rabbit polyclonal antibody to ZBTB33 |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Mol.Wt.: | 74 kDa; 74kD(Calculated). |
| Uniprot: | Q86T24 |
| RRID: | AB_2841497 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8183, RRID:AB_2841497.
Fold/Unfold
Kaiso; Kaiso protein; Kaiso transcription factor; KAISO_HUMAN; Transcriptional regulator Kaiso; ZBTB 33; Zbtb33; Zinc finger and BTB domain containing 33; Zinc finger and BTB domain-containing protein 33; Zinc finger transcription factor Kaiso; ZNF 348; ZNF Kaiso; ZNF348;
Immunogens
- Q86T24 KAISO_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MESRKLISATDIQYSGSLLNSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLFSVAGQVVELSFIRAEIFAEILNYIYSSKIVRVRSDLLDELIKSGQLLGVKFIAELGVPLSQVKSISGTAQDGNTEPLPPDSGDKNLVIQKSKDEAQDNGATIMPIITESFSLSAEDYEMKKIIVTDSDDDDDDVIFCSEILPTKETLPSNNTVAQVQSNPGPVAISDVAPSASNNSPPLTNITPTQKLPTPVNQATLSQTQGSEKLLVSSAPTHLTPNIILLNQTPLSTPPNVSSSLPNHMPSSINLLVQNQQTPNSAILTGNKANEEEEEEIIDDDDDTISSSPDSAVSNTSLVPQADTSQNTSFDGSLIQKMQIPTLLQEPLSNSLKISDIITRNTNDPGVGSKHLMEGQKIITLDTATEIEGLSTGCKVYANIGEDTYDIVIPVKDDPDEGEARLENEIPKTSGSEMANKRMKVKHDDHYELIVDGRVYYICIVCKRSYVCLTSLRRHFNIHSWEKKYPCRYCEKVFPLAEYRTKHEIHHTGERRYQCLACGKSFINYQFMSSHIKSVHSQDPSGDSKLYRLHPCRSLQIRQYAYLSDRSSTIPAMKDDGIGYKVDTGKEPPVGTTTSTQNKPMTWEDIFIQQENDSIFKQNVTDGSTEFEFIIPESY
PTMs - Q86T24 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K5 | Sumoylation | Uniprot | |
| K5 | Ubiquitination | Uniprot | |
| K103 | Ubiquitination | Uniprot | |
| K124 | Ubiquitination | Uniprot | |
| K145 | Ubiquitination | Uniprot | |
| K151 | Sumoylation | Uniprot | |
| K151 | Ubiquitination | Uniprot | |
| K153 | Ubiquitination | Uniprot | |
| T186 | Phosphorylation | Uniprot | |
| S188 | Phosphorylation | Uniprot | |
| S232 | Phosphorylation | Uniprot | |
| S237 | Phosphorylation | Uniprot | |
| T251 | Phosphorylation | Uniprot | |
| S259 | Phosphorylation | Uniprot | |
| S264 | Phosphorylation | Uniprot | |
| K407 | Sumoylation | Uniprot | |
| K407 | Ubiquitination | Uniprot | |
| K414 | Ubiquitination | Uniprot | |
| S428 | Phosphorylation | Uniprot | |
| T441 | Phosphorylation | Uniprot | |
| Y442 | Phosphorylation | Uniprot | |
| K449 | Sumoylation | Uniprot | |
| K449 | Ubiquitination | Uniprot | |
| K465 | Ubiquitination | Uniprot | |
| K474 | Acetylation | Uniprot | |
| K474 | Sumoylation | Uniprot | |
| K474 | Ubiquitination | Uniprot | |
| K479 | Sumoylation | Uniprot | |
| Y484 | Phosphorylation | Uniprot | |
| R491 | Methylation | Uniprot | |
| S517 | Phosphorylation | Uniprot | |
| K529 | Sumoylation | Uniprot | |
| K529 | Ubiquitination | Uniprot | |
| K539 | Ubiquitination | Uniprot | |
| S558 | Phosphorylation | Uniprot | |
| Y562 | Phosphorylation | Uniprot | |
| S567 | Phosphorylation | Uniprot | |
| K570 | Ubiquitination | Uniprot | |
| K582 | Sumoylation | Uniprot | |
| K582 | Ubiquitination | Uniprot | |
| Y599 | Phosphorylation | Uniprot | |
| T606 | Phosphorylation | Uniprot | |
| K611 | Sumoylation | Uniprot | |
| K611 | Ubiquitination | Uniprot | |
| K618 | Sumoylation | Uniprot | |
| K618 | Ubiquitination | Uniprot | |
| K623 | Ubiquitination | Uniprot | |
| T630 | Phosphorylation | Uniprot | |
| T631 | Phosphorylation | Uniprot | |
| K636 | Ubiquitination | Uniprot | |
| T639 | Phosphorylation | Uniprot |
Research Backgrounds
Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1.
Nucleus. Cytoplasm.
Note: Also cytoplasmic in cells grown at high densities.
Expressed in vascular endothelium.
Self-associates. Interacts with CTNND2 (By similarity). Interacts with CTNND1, and this interaction inhibits binding to both methylated and non-methylated DNA. Interacts with NCOR1. Interacts with KPNA2/RCH1, which may mediate nuclear import of this protein. Interacts with CBFA2T3.
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