PTRH2 Antibody - #DF8201

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Product: PTRH2 Antibody
Catalog: DF8201
Description: Rabbit polyclonal antibody to PTRH2
Application: WB
Reactivity: Human, Mouse
Mol.Wt.: 19 kDa; 19kD(Calculated).
Uniprot: Q9Y3E5
RRID: AB_2841509

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Clonality:
Polyclonal
Specificity:
PTRH2 Antibody detects endogenous levels of total PTRH2.
RRID:
AB_2841509
Cite Format: Affinity Biosciences Cat# DF8201, RRID:AB_2841509.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Bcl 2 inhibitor of transcription 1; Bcl-2 inhibitor of transcription 1; BIT 1; BIT1; CGI 147; CGI147; mitochondrial; Peptidyl tRNA hydrolase 2 mitochondrial; Peptidyl-tRNA hydrolase 2; PTH 2; PTH2; PTH2_HUMAN; PTRH 2; PTRH2;

Immunogens

Immunogen:
Uniprot:

Q9Y3E5(PTH2_HUMAN) >>Visit HPA database.

Gene(ID):
PTRH2(51651)
Sequence:
MPSKSLVMEYLAHPSTLGLAVGVACGMCLGWSLRVCFGMLPKSKTSKTHTDTESEASILGDSGEYKMILVVRNDLKMGKGKVAAQCSHAAVSAYKQIQRRNPEMLKQWEYCGQPKVVVKAPDEETLIALLAHAKMLGLTVSLIQDAGRTQIAPGSQTVLGIGPGPADLIDKVTGHLKLY

PTMs - Q9Y3E5 As Substrate

Site PTM Type Enzyme
Ubiquitination
S5 Phosphorylation Q15139 (PRKD1)
T45 Phosphorylation
K47 Ubiquitination
T48 Phosphorylation
T50 Phosphorylation
T52 Phosphorylation
S54 Phosphorylation
S57 Phosphorylation
S62 Phosphorylation
K76 Ubiquitination
K79 Ubiquitination
K81 Ubiquitination
S87 Phosphorylation Q15139 (PRKD1)
Y94 Phosphorylation
K95 Ubiquitination
K106 Acetylation
K106 Ubiquitination
K115 Ubiquitination
K119 Ubiquitination
K134 Ubiquitination
T139 Phosphorylation
K171 Ubiquitination
K177 Ubiquitination

Research Backgrounds

Function:

The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1.

PTMs:

Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.

Subcellular Location:

Mitochondrion.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Monomer.

Family&Domains:

Belongs to the PTH2 family.

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
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