COPS7B Antibody - #DF8376
| Product: | COPS7B Antibody |
| Catalog: | DF8376 |
| Description: | Rabbit polyclonal antibody to COPS7B |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 30 kDa; 30kD(Calculated). |
| Uniprot: | Q9H9Q2 |
| RRID: | AB_2841638 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8376, RRID:AB_2841638.
Fold/Unfold
COP9 Complex Homolog Subunit 7b; COP9 Constitutive Photomorphogenic Homolog Subunit 7b; COP9 Signalasome Subunit 7b; COP9 signalosome complex subunit 7b; COPS7B; CSN7B_HUMAN; JAB1 Containing Signalosome Subunit 7b; JAB1-containing signalosome subunit 7b; SGN7b; Signalosome subunit 7b;
Immunogens
- Q9H9Q2 CSN7B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGEQKPSSNLLEQFILLAKGTSGSALTALISQVLEAPGVYVFGELLELANVQELAEGANAAYLQLLNLFAYGTYPDYIANKESLPELSTAQQNKLKHLTIVSLASRMKCIPYSVLLKDLEMRNLRELEDLIIEAVYTDIIQGKLDQRNQLLEVDFCIGRDIRKKDINNIVKTLHEWCDGCEAVLLGIEQQVLRANQYKENHNRTQQQVEAEVTNIKKTLKATASSSAQEMEQQLAERECPPHAEQRQPTKKMSKVKGLVSSRH
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9H9Q2 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| K95 | Ubiquitination | Uniprot | |
| K109 | Ubiquitination | Uniprot | |
| C110 | S-Nitrosylation | Uniprot | |
| K118 | Ubiquitination | Uniprot | |
| K164 | Ubiquitination | Uniprot | |
| K165 | Ubiquitination | Uniprot | |
| K217 | Ubiquitination | Uniprot | |
| K218 | Ubiquitination | Uniprot | |
| K221 | Ubiquitination | Uniprot | |
| S225 | Phosphorylation | Uniprot | |
| C240 | S-Nitrosylation | Uniprot | |
| S254 | Phosphorylation | Uniprot | |
| K257 | Ubiquitination | Uniprot |
Research Backgrounds
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Cytoplasm. Nucleus.
Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1. In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS5, COPS6 and COPS8. Interacts with EIF3S6.
(Microbial infection) Interacts with vaccinia virus protein C9L.
Belongs to the CSN7/EIF3M family. CSN7 subfamily.
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