TMEFF2 Antibody - #DF8405
| Product: | TMEFF2 Antibody |
| Catalog: | DF8405 |
| Description: | Rabbit polyclonal antibody to TMEFF2 |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 41 kDa; 41kD(Calculated). |
| Uniprot: | Q9UIK5 |
| RRID: | AB_2841656 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8405, RRID:AB_2841656.
Fold/Unfold
Cancer/testis antigen family 120 member 2; CT120.2; HPP 1; HPP1; Hyperplastic polyposis protein 1; TEFF 2; TEFF2; TEFF2_HUMAN; TENB 2; TENB2; TMEFF2; Tomoregulin; Tomoregulin-2; TPEF; TR 2; TR; TR-2; Transmembrane protein containing epidermal growth factor and follistatin domains; Transmembrane protein TENB2; Transmembrane protein with EGF like and two follistatin like domains 2; Transmembrane protein with EGF-like and two follistatin-like domains;
Immunogens
Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level). Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate.
- Q9UIK5 TEFF2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVLWESPRQCSSWTLCEGFCWLLLLPVMLLIVARPVKLAAFPTSLSDCQTPTGWNCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTCDICQFGAECDEDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQDNTTTTTKSEDGHYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINMQEPSCRCDAGYTGQHCEKKDYSVLYVVPGPVRFQYVLIAAVIGTIQIAVICVVVLCITRKCPRSNRIHRQKQNTGHYSSDNTTRASTRLI
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9UIK5 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y202 | Phosphorylation | Uniprot | |
| N204 | N-Glycosylation | Uniprot | |
| T231 | Phosphorylation | Uniprot | |
| Y309 | Phosphorylation | Uniprot | |
| Y319 | Phosphorylation | Uniprot | |
| T358 | Phosphorylation | Uniprot | |
| Y361 | Phosphorylation | Uniprot | |
| S362 | Phosphorylation | Uniprot | |
| S363 | Phosphorylation | Uniprot |
Research Backgrounds
May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.
N-glycosylated. Contains chondroitin sulfate glycosaminoglycans.
A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or proinflammatory cytokines such as TNFalpha, and is mediated by ADAM17.
Membrane>Single-pass type I membrane protein.
Membrane>Single-pass type I membrane protein.
Secreted.
Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level). Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate.
Belongs to the tomoregulin family.
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