Calcitonin Antibody - #DF8512
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8512, RRID:AB_2841717.
Fold/Unfold
Calcitonin/calcitonin related polypeptide alpha; Alpha type CGRP; Beta type CGRP; CALC1; CALC2; CALCA; CALCB; Calcitonin 1; Calcitonin 2; Calcitonin gene related peptide I; Calcitonin gene related peptide II; Calcitonin related polypeptide alpha; Calcitonin related polypeptide beta; CGRP; CGRP I; CGRP II; CGRP1; CGRP2; CT; Katacalcin; KC; Alpha CGRP; alpha type CGRP; CALC 1; CALC A; CALC1; calcitonin 1; calcitonin gene related peptide 1; calcitonin gene related peptide I; calcitonin related polypeptide alpha; CGRP 1; CGRP; CGRP I; CGRP1; CT; katacalcin; KC;
Immunogens
A synthesized peptide derived from human Calcitonin, corresponding to a region within the internal amino acids.
- P06881 CALCA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGFQKFSPFLALSILVLLQAGSLHAAPFRSALESSPADPATLSEDEARLLLAALVQDYVQMKASELEQEQEREGSRIIAQKRACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAFGRRRRDLQA
- P01258 CALC_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGFQKFSPFLALSILVLLQAGSLHAAPFRSALESSPADPATLSEDEARLLLAALVQDYVQMKASELEQEQEREGSSLDSPRSKRCGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAPGKKRDMSSDLERDHRPHVSMPQNAN
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P06881/P01258 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S99 | Phosphorylation | Uniprot | |
| S101 | Phosphorylation | Uniprot |
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S35 | Phosphorylation | Uniprot | |
| T41 | Phosphorylation | Uniprot | |
| T105 | O-Glycosylation | Uniprot | |
| T105 | Phosphorylation | Uniprot | |
| T109 | O-Glycosylation | Uniprot |
Research Backgrounds
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.
Secreted.
Belongs to the calcitonin family.
Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
Katacalcin is a potent plasma calcium-lowering peptide.
Secreted.
Belongs to the calcitonin family.
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