CHD1L Antibody - #DF8521
| Product: | CHD1L Antibody |
| Catalog: | DF8521 |
| Description: | Rabbit polyclonal antibody to CHD1L |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 101 kDa; 101kD(Calculated). |
| Uniprot: | Q86WJ1 |
| RRID: | AB_2841726 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8521, RRID:AB_2841726.
Fold/Unfold
ALC1; Amplified in liver cancer 1; Amplified in liver cancer protein 1; chd1l; CHD1L_HUMAN; CHDL; Chromodomain helicase DNA binding protein 1 like; Chromodomain-helicase-DNA-binding protein 1-like; FLJ22530;
Immunogens
- Q86WJ1 CHD1L_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MERAGATSRGGQAPGFLLRLHTEGRAEAARVQEQDLRQWGLTGIHLRSYQLEGVNWLAQRFHCQNGCILGDEMGLGKTCQTIALFIYLAGRLNDEGPFLILCPLSVLSNWKEEMQRFAPGLSCVTYAGDKEERACLQQDLKQESRFHVLLTTYEICLKDASFLKSFPWSVLVVDEAHRLKNQSSLLHKTLSEFSVVFSLLLTGTPIQNSLQELYSLLSFVEPDLFSKEEVGDFIQRYQDIEKESESASELHKLLQPFLLRRVKAEVATELPKKTEVVIYHGMSALQKKYYKAILMKDLDAFENETAKKVKLQNILSQLRKCVDHPYLFDGVEPEPFEVGDHLTEASGKLHLLDKLLAFLYSGGHRVLLFSQMTQMLDILQDYMDYRGYSYERVDGSVRGEERHLAIKNFGQQPIFVFLLSTRAGGVGMNLTAADTVIFVDSDFNPQNDLQAAARAHRIGQNKSVKVIRLIGRDTVEEIVYRKAASKLQLTNMIIEGGHFTLGAQKPAADADLQLSEILKFGLDKLLASEGSTMDEIDLESILGETKDGQWVSDALPAAEGGSRDQEEGKNHMYLFEGKDYSKEPSKEDRKSFEQLVNLQKTLLEKASQEGRSLRNKGSVLIPGLVEGSTKRKRVLSPEELEDRQKKRQEAAAKRRRLIEEKKRQKEEAEHKKKMAWWESNNYQSFCLPSEESEPEDLENGEESSAELDYQDPDATSLKYVSGDVTHPQAGAEDALIVHCVDDSGHWGRGGLFTALEKRSAEPRKIYELAGKMKDLSLGGVLLFPVDDKESRNKGQDLLALIVAQHRDRSNVLSGIKMAALEEGLKKIFLAAKKKKASVHLPRIGHATKGFNWYGTERLIRKHLAARGIPTYIYYFPRSKSAVLHSQSSSSSSRQLVP
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q86WJ1 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R9 | Methylation | Uniprot | |
| S122 | Phosphorylation | Uniprot | |
| K130 | Ubiquitination | Uniprot | |
| K141 | Ubiquitination | Uniprot | |
| K180 | Ubiquitination | Uniprot | |
| K242 | Ubiquitination | Uniprot | |
| K252 | Ubiquitination | Uniprot | |
| K263 | Sumoylation | Uniprot | |
| K263 | Ubiquitination | Uniprot | |
| Y279 | Phosphorylation | Uniprot | |
| S283 | Phosphorylation | Uniprot | |
| Y289 | Phosphorylation | Uniprot | |
| Y290 | Phosphorylation | Uniprot | |
| K291 | Ubiquitination | Uniprot | |
| K296 | Ubiquitination | Uniprot | |
| K307 | Ubiquitination | Uniprot | |
| K310 | Ubiquitination | Uniprot | |
| K320 | Ubiquitination | Uniprot | |
| K348 | Ubiquitination | Uniprot | |
| K524 | Ubiquitination | Uniprot | |
| S540 | Phosphorylation | Uniprot | |
| K546 | Sumoylation | Uniprot | |
| S562 | Phosphorylation | Uniprot | |
| K569 | Ubiquitination | Uniprot | |
| K590 | Sumoylation | Uniprot | |
| K590 | Ubiquitination | Uniprot | |
| S591 | Phosphorylation | Uniprot | |
| K600 | Ubiquitination | Uniprot | |
| K605 | Ubiquitination | Uniprot | |
| S607 | Phosphorylation | Uniprot | |
| S612 | Phosphorylation | Uniprot | |
| K616 | Ubiquitination | Uniprot | |
| S618 | Phosphorylation | Uniprot | |
| S628 | Phosphorylation | Uniprot | |
| T629 | Phosphorylation | Uniprot | |
| K630 | Ubiquitination | Uniprot | |
| S636 | Phosphorylation | Uniprot | |
| Y709 | Phosphorylation | Uniprot | |
| T753 | Phosphorylation | Uniprot | |
| K757 | Ubiquitination | Uniprot | |
| K764 | Ubiquitination | Uniprot | |
| K771 | Ubiquitination | Uniprot | |
| S776 | Phosphorylation | Uniprot | |
| K788 | Ubiquitination | Uniprot | |
| K793 | Ubiquitination | Uniprot | |
| S809 | Phosphorylation | Uniprot | |
| Y871 | Phosphorylation | Uniprot | |
| Y873 | Phosphorylation | Uniprot | |
| S891 | Phosphorylation | Uniprot |
Research Backgrounds
DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding.
Nucleus.
Note: Localizes at sites of DNA damage. Probably recruited to DNA damage sites by PARylated PARP1.
Frequently overexpressed in hepatomacellular carcinomas.
Interacts with PARP1; interacts only when PARP1 is poly-ADP-ribosylated (PARylated). Interacts with CIAO1.
The macro domain mediates non-covalent poly(ADP-ribose)-binding and recruitment to DNA damage sites.
Belongs to the SNF2/RAD54 helicase family.
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