PDLIM5 Antibody - #DF8590
| Product: | PDLIM5 Antibody |
| Catalog: | DF8590 |
| Description: | Rabbit polyclonal antibody to PDLIM5 |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Horse, Sheep, Dog |
| Mol.Wt.: | 64 kDa; 64kD(Calculated). |
| Uniprot: | Q96HC4 |
| RRID: | AB_2841794 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8590, RRID:AB_2841794.
Fold/Unfold
ENH; ENH1; Enigma homolog; Enigma like LIM domain protein; Enigma like PDZ and LIM domains protein; Enigma-like PDZ and LIM domains protein; L 9; L9; LIM; PDLI5_HUMAN; PDLIM5; PDZ and LIM domain 5; PDZ and LIM domain protein 5;
Immunogens
Heart and skeletal muscle specific. Expression is commonly increased in the brain of patients with bipolar disorder, schizophrenia, and major depression.
- Q96HC4 PDLI5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKGEPKEVVKPVPITSPAVSKVTSTNNMAYNKAPRPFGSVSSPKVTSIPSPSSAFTPAHATTSSHASPSPVAAVTPPLFAASGLHANANLSADQSPSALSAGKTAVNVPRQPTVTSVCSETSQELAEGQRRGSQGDSKQQNGPPRKHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTEHLKESEADNTKKANNSQEPSPQLASSVASTRSMPESLDSPTSGRPGVTSLTAAAAFKPVGSTGVIKSPSWQRPNQGVPSTGRISNSATYSGSVAPANSALGQTQPSDQDTLVQRAEHIPAGKRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHSVNF
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q96HC4 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| S2 | Phosphorylation | Uniprot | |
| S5 | Phosphorylation | Uniprot | |
| S31 | Phosphorylation | Uniprot | |
| K34 | Ubiquitination | Uniprot | |
| S76 | Phosphorylation | Uniprot | |
| T80 | Phosphorylation | Uniprot | |
| K89 | Sumoylation | Uniprot | |
| K89 | Ubiquitination | Uniprot | |
| K105 | Acetylation | Uniprot | |
| T110 | O-Glycosylation | Uniprot | |
| T110 | Phosphorylation | Uniprot | |
| S111 | Phosphorylation | Uniprot | |
| S119 | Phosphorylation | Uniprot | |
| Y125 | Phosphorylation | Uniprot | |
| S134 | Phosphorylation | Uniprot | |
| S136 | Phosphorylation | Uniprot | |
| S137 | Phosphorylation | Uniprot | |
| T199 | Phosphorylation | Uniprot | |
| T208 | Phosphorylation | Uniprot | |
| S211 | Phosphorylation | Uniprot | |
| C213 | S-Nitrosylation | Uniprot | |
| S214 | Phosphorylation | Uniprot | |
| T216 | Phosphorylation | Uniprot | |
| S217 | Phosphorylation | Uniprot | |
| S228 | Phosphorylation | Uniprot | |
| S232 | Phosphorylation | Uniprot | |
| Y247 | Phosphorylation | Uniprot | |
| T248 | Phosphorylation | Uniprot | |
| Y251 | Phosphorylation | Uniprot | |
| T255 | Phosphorylation | Uniprot | |
| S257 | Phosphorylation | Uniprot | |
| S260 | Phosphorylation | Uniprot | |
| K261 | Acetylation | Uniprot | |
| K261 | Ubiquitination | Uniprot | |
| K262 | Acetylation | Uniprot | |
| S282 | Phosphorylation | Uniprot | |
| T290 | Phosphorylation | Uniprot | |
| K296 | Ubiquitination | Uniprot | |
| K305 | Ubiquitination | Uniprot | |
| S309 | Phosphorylation | Uniprot | |
| S313 | Phosphorylation | Uniprot | |
| S319 | Phosphorylation | Uniprot | |
| S332 | Phosphorylation | Uniprot | |
| T355 | Phosphorylation | Uniprot | |
| S360 | Phosphorylation | Uniprot | |
| S362 | Phosphorylation | Uniprot | |
| S372 | Phosphorylation | Uniprot | |
| T373 | Phosphorylation | Uniprot | |
| R375 | Methylation | Uniprot | |
| T381 | Phosphorylation | Uniprot | |
| Y382 | Phosphorylation | Uniprot | |
| K415 | Ubiquitination | Uniprot | |
| T417 | Phosphorylation | Uniprot | |
| C423 | S-Nitrosylation | Uniprot | |
| T452 | Phosphorylation | Uniprot | |
| Y455 | Phosphorylation | Uniprot | |
| Y466 | Phosphorylation | Uniprot | |
| K485 | Ubiquitination | Uniprot | |
| K589 | Ubiquitination | Uniprot | |
| S593 | Phosphorylation | Uniprot |
Research Backgrounds
May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity).
Cell junction>Synapse>Postsynaptic density. Cell junction>Synapse>Presynapse. Cell junction>Synapse>Postsynapse. Cytoplasm>Cytosol.
Note: Detected both at presynaptic and postsynaptic sites, exclusively at excitatory synapses, but not inhibitory synapses, in hippocampal neurons.
Heart and skeletal muscle specific. Expression is commonly increased in the brain of patients with bipolar disorder, schizophrenia, and major depression.
Interacts with various PKC isoforms through the LIM domains. Interacts (via LIM domains) with SIPA1L1. Interacts (via PDZ domain) with actin and ACTN1 (By similarity).
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