Tensin-1 Antibody - #DF8622

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Product: Tensin-1 Antibody
Catalog: DF8622
Description: Rabbit polyclonal antibody to Tensin-1
Application: WB IF/ICC
Reactivity: Human, Mouse
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
Mol.Wt.: 185 kDa; 186kD(Calculated).
Uniprot: Q9HBL0
RRID: AB_2841826

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Prediction:
Pig(83%), Bovine(92%), Horse(100%), Sheep(92%), Rabbit(100%), Dog(100%), Chicken(83%)
Clonality:
Polyclonal
Specificity:
Tensin-1 Antibody detects endogenous levels of total Tensin-1.
RRID:
AB_2841826
Cite Format: Affinity Biosciences Cat# DF8622, RRID:AB_2841826.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

matrix-remodelling associated 6; Matrix-remodelling-associated protein 6; MGC88584; MST091; MST122; MST127; MSTP091; MSTP122; MSTP127; MXRA6; TENS1_HUMAN; Tensin; Tensin-1; TNS; TNS1;

Immunogens

Immunogen:
Uniprot:

Q9HBL0(TENS1_HUMAN) >>Visit HPA database.

Gene(ID):
TNS1(7145)
Expression:
Q9HBL0 TENS1_HUMAN:

Ubiquitous.

Sequence:
MSVSRTMEDSCELDLVYVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNLSERRPDITKLHAKVLEFGWPDLHTPALEKICSICKAMDTWLNADPHNVVVLHNKGNRGRIGVVIAAYMHYSNISASADQALDRFAMKRFYEDKIVPIGQPSQRRYVHYFSGLLSGSIKMNNKPLFLHHVIMHGIPNFESKGGCRPFLRIYQAMQPVYTSGIYNIPGDSQTSVCITIEPGLLLKGDILLKCYHKKFRSPARDVIFRVQFHTCAIHDLGVVFGKEDLDDAFKDDRFPEYGKVEFVFSYGPEKIQGMEHLENGPSVSVDYNTSDPLIRWDSYDNFSGHRDDGMEEVVGHTQGPLDGSLYAKVKKKDSLHGSTGAVNATRPTLSATPNHVEHTLSVSSDSGNSTASTKTDKTDEPVPGASSATAALSPQEKRELDRLLSGFGLEREKQGAMYHTQHLRSRPAGGSAVPSSGRHVVPAQVHVNGGALASERETDILDDELPNQDGHSAGSMGTLSSLDGVTNTSEGGYPEALSPLTNGLDKSYPMEPMVNGGGYPYESASRAGPAHAGHTAPMRPSYSAQEGLAGYQREGPHPAWPQPVTTSHYAHDPSGMFRSQSFSEAEPQLPPAPVRGGSSREAVQRGLNSWQQQQQQQQQPRPPPRQQERAHLESLVASRPSPQPLAETPIPSLPEFPRAASQQEIEQSIETLNMLMLDLEPASAAAPLHKSQSVPGAWPGASPLSSQPLSGSSRQSHPLTQSRSGYIPSGHSLGTPEPAPRASLESVPPGRSYSPYDYQPCLAGPNQDFHSKSPASSSLPAFLPTTHSPPGPQQPPASLPGLTAQPLLSPKEATSDPSRTPEEEPLNLEGLVAHRVAGVQAREKQPAEPPAPLRRRAASDGQYENQSPEATSPRSPGVRSPVQCVSPELALTIALNPGGRPKEPHLHSYKEAFEEMEGTSPSSPPPSGVRSPPGLAKTPLSALGLKPHNPADILLHPTGVTRRRIQPEEDEGKVVVRLSEEPRSYVESVARTAVAGPRAQDSEPKSFSAPATQAYGHEIPLRNGTLGGSFVSPSPLSTSSPILSADSTSVGSFPSGESSDQGPRTPTQPLLESGFRSGSLGQPSPSAQRNYQSSSPLPTVGSSYSSPDYSLQHFSSSPESQARAQFSVAGVHTVPGSPQARHRTVGTNTPPSPGFGWRAINPSMAAPSSPSLSHHQMMGPPGTGFHGSTVSSPQSSAATTPGSPSLCRHPAGVYQVSGLHNKVATTPGSPSLGRHPGAHQGNLASGLHSNAIASPGSPSLGRHLGGSGSVVPGSPCLDRHVAYGGYSTPEDRRPTLSRQSSASGYQAPSTPSFPVSPAYYPGLSSPATSPSPDSAAFRQGSPTPALPEKRRMSVGDRAGSLPNYATINGKVSSPVASGMSSPSGGSTVSFSHTLPDFSKYSMPDNSPETRAKVKFVQDTSKYWYKPEISREQAIALLKDQEPGAFIIRDSHSFRGAYGLAMKVSSPPPTIMQQNKKGDMTHELVRHFLIETGPRGVKLKGCPNEPNFGSLSALVYQHSIIPLALPCKLVIPNRDPTDESKDSSGPANSTADLLKQGAACNVLFVNSVDMESLTGPQAISKATSETLAADPTPAATIVHFKVSAQGITLTDNQRKLFFRRHYPLNTVTFCDLDPQERKWMKTEGGAPAKLFGFVARKQGSTTDNACHLFAELDPNQPASAIVNFVSKVMLNAGQKR

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
100
Dog
100
Rabbit
100
Bovine
92
Sheep
92
Pig
83
Chicken
83
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9HBL0 As Substrate

Site PTM Type Enzyme
S2 Phosphorylation
S4 Phosphorylation
T68 Phosphorylation
K69 Ubiquitination
T84 Phosphorylation
S92 Phosphorylation
S170 Phosphorylation
Y210 Phosphorylation
Y217 Phosphorylation
K249 Ubiquitination
S257 Phosphorylation
K290 Ubiquitination
Y327 Phosphorylation
T329 Phosphorylation
S330 Phosphorylation
S338 Phosphorylation
Y339 Phosphorylation
S343 Phosphorylation
T357 Phosphorylation
S364 Phosphorylation
Y366 Phosphorylation
S374 Phosphorylation
S378 Phosphorylation
T379 Phosphorylation
S390 Phosphorylation
T399 Phosphorylation
S401 Phosphorylation
S403 Phosphorylation
S404 Phosphorylation
S406 Phosphorylation
S433 Phosphorylation
K437 Ubiquitination
S445 Phosphorylation
Y458 Phosphorylation
T460 Phosphorylation
S465 Phosphorylation
S471 Phosphorylation
S475 Phosphorylation
T498 Phosphorylation
S512 Phosphorylation
T518 Phosphorylation
S538 Phosphorylation
S547 Phosphorylation
Y561 Phosphorylation
T575 Phosphorylation
Y582 Phosphorylation
S583 Phosphorylation
Y591 Phosphorylation
T605 Phosphorylation
T606 Phosphorylation
S607 Phosphorylation
Y609 Phosphorylation
S614 Phosphorylation
S619 Phosphorylation
S621 Phosphorylation
S623 Phosphorylation
S638 Phosphorylation
S649 Phosphorylation
S674 Phosphorylation
S681 Phosphorylation
T688 Phosphorylation
S692 Phosphorylation
S701 Phosphorylation
S708 Phosphorylation
T711 Phosphorylation
S731 Phosphorylation
S733 Phosphorylation
S742 Phosphorylation
S746 Phosphorylation
S756 Phosphorylation
S762 Phosphorylation
S764 Phosphorylation
Y766 Phosphorylation
S769 Phosphorylation
S772 Phosphorylation
T775 Phosphorylation
S783 Phosphorylation
S786 Phosphorylation
Y793 Phosphorylation
S794 Phosphorylation
Y796 Phosphorylation
Y798 Phosphorylation
S813 Phosphorylation
S838 Phosphorylation
T843 Phosphorylation
S849 Phosphorylation
T854 Phosphorylation
S855 Phosphorylation
S858 Phosphorylation
T860 Phosphorylation
S899 Phosphorylation
Y903 Phosphorylation
S907 Phosphorylation
T911 Phosphorylation
S912 Phosphorylation
S915 Phosphorylation
S920 Phosphorylation
S926 Phosphorylation
S948 Phosphorylation
T959 Phosphorylation
S960 Phosphorylation
S962 Phosphorylation
S963 Phosphorylation
S967 Phosphorylation
S971 Phosphorylation
S981 Phosphorylation
S1019 Phosphorylation
S1024 Phosphorylation
Y1025 Phosphorylation
S1046 Phosphorylation
S1048 Phosphorylation
Y1055 Phosphorylation
T1105 Phosphorylation
T1107 Phosphorylation
S1113 Phosphorylation
S1117 Phosphorylation
S1119 Phosphorylation
S1124 Phosphorylation
S1126 Phosphorylation
Y1131 Phosphorylation
S1133 Phosphorylation
S1135 Phosphorylation
T1139 Phosphorylation
S1142 Phosphorylation
S1143 Phosphorylation
Y1144 Phosphorylation
S1145 Phosphorylation
S1146 Phosphorylation
Y1149 Phosphorylation
S1150 Phosphorylation
S1155 Phosphorylation
S1156 Phosphorylation
S1157 Phosphorylation
S1160 Phosphorylation
S1167 Phosphorylation
T1173 Phosphorylation
S1177 Phosphorylation
T1184 Phosphorylation
T1189 Phosphorylation
S1192 Phosphorylation
S1209 Phosphorylation
S1232 Phosphorylation
S1243 Phosphorylation
Y1254 Phosphorylation
S1257 Phosphorylation
T1265 Phosphorylation
T1266 Phosphorylation
S1269 Phosphorylation
S1271 Phosphorylation
S1294 Phosphorylation
S1297 Phosphorylation
S1307 Phosphorylation
S1309 Phosphorylation
S1314 Phosphorylation
Y1323 Phosphorylation
Y1326 Phosphorylation
S1327 Phosphorylation
T1328 Phosphorylation
T1335 Phosphorylation
S1337 Phosphorylation
S1340 Phosphorylation
S1343 Phosphorylation
Y1345 Phosphorylation
S1349 Phosphorylation
Y1359 Phosphorylation
S1371 Phosphorylation
S1381 Phosphorylation
T1383 Phosphorylation
S1393 Phosphorylation
S1400 Phosphorylation
Y1404 Phosphorylation
T1406 Phosphorylation
S1413 Phosphorylation
S1417 Phosphorylation
S1420 Phosphorylation
S1421 Phosphorylation
S1423 Phosphorylation
S1426 Phosphorylation
Y1440 Phosphorylation
S1441 Phosphorylation
S1446 Phosphorylation
K1454 Ubiquitination
Y1462 Phosphorylation
S1490 Phosphorylation
S1492 Phosphorylation
T1509 Phosphorylation
S1579 Phosphorylation
K1580 Ubiquitination
S1583 Phosphorylation
S1588 Phosphorylation
T1589 Phosphorylation
T1665 Phosphorylation
T1667 Phosphorylation

Research Backgrounds

Function:

Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.

PTMs:

Rapidly cleaved by calpain II.

Subcellular Location:

Cell surface. Cell junction>Focal adhesion. Cytoplasm>Cytoskeleton.
Note: Localized at cell periphery preferentially to fibrillar adhesions than focal adhesions. Translocates from the cell edge to cell center in an ITGB1BP1-dependent manner.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Ubiquitous.

Subunit Structure:

Binds to actin filaments and interacts with phosphotyrosine-containing proteins. Interacts with STARD8.

Family&Domains:

Belongs to the PTEN phosphatase protein family.

Restrictive clause

 

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