ZFP106 Antibody - #DF8630

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Product: ZFP106 Antibody
Catalog: DF8630
Description: Rabbit polyclonal antibody to ZFP106
Application: WB IHC
Reactivity: Human, Mouse
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog
Mol.Wt.: 208 kDa; 209kD(Calculated).
Uniprot: Q9H2Y7
RRID: AB_2841834

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IHC 1:50-1:200, WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Prediction:
Pig(88%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%)
Clonality:
Polyclonal
Specificity:
ZFP106 Antibody detects endogenous levels of total ZFP106.
RRID:
AB_2841834
Cite Format: Affinity Biosciences Cat# DF8630, RRID:AB_2841834.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

DKFZp451A239; FLJ34610; FLJ45841; SH3 domain binding protein 3; SH3BP3; Zfp 106; Zinc finger protein 106 homolog (mouse); Zinc finger protein 106 homolog; Zinc finger protein 474; ZNF474;

Immunogens

Immunogen:
Uniprot:

Q9H2Y7(ZN106_HUMAN) >>Visit HPA database.

Gene(ID):
ZNF106(64397)
Sequence:
MPVGRIECPSSPSFPRDISHECRVCGVTEVGLSAYAKHISGQLHKDNVDAQEREDDGKGEEEEEDYFDKELIQLIKQRKEQSRQDEPSNSNQEINSDDRRPQWRREDRIPYQDRESYSQPAWHHRGPPQRDWKWEKDGFNNTRKNSFPHSLRNGGGPRGRSGWHKGVAGGSSTWFHNHSNSGGGWLSNSGAVDWNHNGTGRNSSWLSEGTGGFSSWHMNNSNGNWKSSVRSTNNWNYSGPGDKFQPGRNRNSNCQMEDMTMLWNKKSNKSNKYSHDRYNWQRQENDKLGTVATYRGPSEGFTSDKFPSEGLLDFNFEQLESQTTKQADTATSKVSGKNGSAAREKPRRWTPYPSQKTLDLQSGLKDITGNKSEMIEKPLFDFSLITTGIQEPQTDETRNSPTQKTQKEIHTGSLNHKASSDSAASFEVVRQCPTAEKPEQEHTPNKMPSLKSPLLPCPATKSLSQKQDPKNISKNTKTNFFSPGEHSNPSNKPTVEDNHGPYISKLRSSCPHVLKGNKSTFGSQKQSGDNLNDTLRKAKEVLQCHESLQNPLLSTSKSTRNYAKASRNVEESEKGSLKIEFQVHALEDESDGETSDTEKHGTKIGTLGSATTELLSGSTRTADEKEEDDRILKTSRELSTSPCNPIVRQKESELQMTSAASPHPGLLLDLKTSLEDAQVDDSIKSHVSYETEGFESASLDAELQKSDISQPSGPLLPELSKLGFPASLQRDLTRHISLKSKTGVHLPEPNLNSARRIRNISGHRKSETEKESGLKPTLRQILNASRRNVNWEQVIQQVTKKKQELGKGLPRFGIEMVPLVQNEQEALDLDGEPDLSSLEGFQWEGVSISSSPGLARKRSLSESSVIMDRAPSVYSFFSEEGTGKENEPQQMVSPSNSLRAGQSQKATMHLKQEVTPRAASLRTGERAENVATQRRHSAQLSSDHIIPLMHLAKDLNSQERSIPPSENQNSQESNGEGNCLSSSASSALAISSLADAATDSSCTSGAEQNDGQSIRKKRRATGDGSSPELPSLERKNKRRKIKGKKERSQVDQLLNISLREEELSKSLQCMDNNLLQARAALQTAYVEVQRLLMLKQQITMEMSALRTHRIQILQGLQETYEPSEHPDQVPCSLTRERRNSRSQTSIDAALLPTPFFPLFLEPPSSHVSPSPTGASLQITTSPTFQTHGSVPAPDSSVQIKQEPMSPEQDENVNAVPPSSACNVSKELLEANREISDSCPVYPVITARLSLPESTESFHEPSQELKFSVEQRNTRNRENSPSSQSAGLSSINKEGEEPTKGNSGSEACTSSFLRLSFASETPLEKEPHSPADQPEQQAESTLTSAETRGSKKKKKLRKKKSLRAAHVPENSDTEQDVLTVKPVRKVKAGKLIKGGKVTTSTWEDSRTGREQESVRDEPDSDSSLEVLEIPNPQLEVVAIDSSESGEEKPDSPSKKDIWNSTEQNPLETSRSGCDEVSSTSEIGTRYKDGIPVSVAETQTVISSIKGSKNSSEISSEPGDDDEPTEGSFEGHQAAVNAIQIFGNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVTQTSGKNAALYTGSSDHTIRCYNVKSRECVEQLQLEDRVLCLHSRWRILYAGLANGTVVTFNIKNNKRLEIFECHGPRAVSCLATAQEGARKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTILCMKVVNDLVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNILGKVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKSMIYTGCYDGSIQAVRLNLMQNYRCWWHGCSLIFGVVDHLKQHLLTDHTNPNFQTLKCRWKNCDAFFTARKGSKQDAAGHIERHAEDDSKIDS

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Pig
88
Chicken
75
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9H2Y7 As Substrate

Site PTM Type Enzyme
S11 Phosphorylation
K45 Ubiquitination
Y66 Phosphorylation
K69 Ubiquitination
K76 Sumoylation
K76 Ubiquitination
K133 Sumoylation
K136 Ubiquitination
K144 Sumoylation
S146 Phosphorylation
S150 Phosphorylation
S231 Phosphorylation
S238 Phosphorylation
K243 Sumoylation
K243 Ubiquitination
K287 Ubiquitination
K305 Ubiquitination
K325 Ubiquitination
K356 Sumoylation
K356 Ubiquitination
K365 Sumoylation
K365 Ubiquitination
K371 Sumoylation
K371 Ubiquitination
T394 Phosphorylation
S400 Phosphorylation
S422 Phosphorylation
T443 Phosphorylation
S452 Phosphorylation
S482 Phosphorylation
K505 Ubiquitination
K525 Sumoylation
K525 Ubiquitination
S527 Phosphorylation
T534 Phosphorylation
K539 Ubiquitination
S554 Phosphorylation
K557 Ubiquitination
Y562 Phosphorylation
K564 Ubiquitination
S572 Phosphorylation
K574 Methylation
K578 Sumoylation
S590 Phosphorylation
S595 Phosphorylation
T602 Phosphorylation
K603 Ubiquitination
S616 Phosphorylation
S639 Phosphorylation
T640 Phosphorylation
S641 Phosphorylation
K650 Ubiquitination
S661 Phosphorylation
K671 Ubiquitination
K721 Ubiquitination
S727 Phosphorylation
K739 Ubiquitination
T742 Phosphorylation
S753 Phosphorylation
S761 Phosphorylation
S766 Phosphorylation
K770 Ubiquitination
K775 Sumoylation
K775 Ubiquitination
S785 Phosphorylation
K807 Ubiquitination
S851 Phosphorylation
S859 Phosphorylation
S861 Phosphorylation
S863 Phosphorylation
S864 Phosphorylation
S872 Phosphorylation
S878 Phosphorylation
S893 Phosphorylation
S897 Phosphorylation
K905 Ubiquitination
K911 Sumoylation
T915 Phosphorylation
T932 Phosphorylation
S937 Phosphorylation
S941 Phosphorylation
S942 Phosphorylation
T1021 Phosphorylation
S1025 Phosphorylation
S1026 Phosphorylation
S1031 Phosphorylation
T1099 Phosphorylation
S1103 Phosphorylation
S1140 Phosphorylation
K1200 Sumoylation
S1205 Phosphorylation
S1249 Phosphorylation
S1253 Phosphorylation
T1254 Phosphorylation
S1256 Phosphorylation
S1261 Phosphorylation
K1265 Sumoylation
S1279 Phosphorylation
S1281 Phosphorylation
S1282 Phosphorylation
S1284 Phosphorylation
S1302 Phosphorylation
S1304 Phosphorylation
S1315 Phosphorylation
S1318 Phosphorylation
T1320 Phosphorylation
S1328 Phosphorylation
T1346 Phosphorylation
K1350 Acetylation
K1351 Acetylation
K1352 Acetylation
K1358 Acetylation
S1360 Phosphorylation
S1370 Phosphorylation
T1372 Phosphorylation
T1378 Phosphorylation
K1395 Sumoylation
T1397 Phosphorylation
T1398 Phosphorylation
S1399 Phosphorylation
S1404 Phosphorylation
S1468 Phosphorylation
S1470 Phosphorylation
K1486 Sumoylation
K1486 Ubiquitination
K1504 Sumoylation
K1504 Ubiquitination
S1560 Phosphorylation
K1585 Sumoylation
T1636 Phosphorylation
K1737 Sumoylation
T1858 Phosphorylation

Research Backgrounds

Function:

RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism.

PTMs:

Phosphorylated by FYN in vitro.

Subcellular Location:

Nucleus>Nucleolus. Nucleus speckle.
Note: Colocalizes with RBM39 in nuclear speckles. Inhibition of RNA synthesis, or overexpression of KNOP1, induces translocation from nuclear speckles to the nucleolus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Interacts with KNOP1. Interacts with TARDBP and NUP107. Interacts (via N-terminus) with RBM39. Interacts with the SH3 domains of FYN and GRB2.

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