DOK5 Antibody - #DF8651
| Product: | DOK5 Antibody |
| Catalog: | DF8651 |
| Description: | Rabbit polyclonal antibody to DOK5 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Bovine, Horse, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 35 kDa; 35kD(Calculated). |
| Uniprot: | Q9P104 |
| RRID: | AB_2841855 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8651, RRID:AB_2841855.
Fold/Unfold
chromosome 20 open reading frame 180; Docking protein 5; DOK 5; DOK5; DOK5 protein; DOK5_HUMAN; Downstream of tyrosine kinase 5; Insulin receptor substrate 6; IRS-6; IRS6;
Immunogens
Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes.
- Q9P104 DOK5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASNFNDIVKQGYVRIRSRRLGIYQRCWLVFKKASSKGPKRLEKFSDERAAYFRCYHKVTELNNVKNVARLPKSTKKHAIGIYFNDDTSKTFACESDLEADEWCKVLQMECVGTRINDISLGEPDLLATGVEREQSERFNVYLMPSPNLDVHGECALQITYEYICLWDVQNPRVKLISWPLSALRRYGRDTTWFTFEAGRMCETGEGLFIFQTRDGEAIYQKVHSAALAIAEQHERLLQSVKNSMLQMKMSERAASLSTMVPLPRSAYWQHITRQHSTGQLYRLQDVSSPLKLHRTETFPAYRSEH
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9P104 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K37 | Acetylation | Uniprot | |
| S277 | Phosphorylation | Uniprot |
Research Backgrounds
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.
Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF.
Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes.
Interacts with phosphorylated RET. In contrast to other DOK proteins, it does not interact with RASGAP (By similarity).
PTB domain mediates receptor interaction.
Belongs to the DOK family. Type B subfamily.
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