FAKD2 Antibody - #DF8656
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8656, RRID:AB_2841860.
Fold/Unfold
FAKD2_HUMAN; FAST kinase domain containing protein 2; FAST kinase domain-containing protein 2; FAST kinase domains 2; Fastkd2; KIAA0971;
Immunogens
Expression detected in spleen, thymus, testis, ovary, colon, heart, smooth muscle, kidney, brain, lung, liver and white adipose tissue with highest expression in heart, smooth muscle and thyroid.
- Q9NYY8 FAKD2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLTTLKPFGSVSVESKMNNKAGSFFWNLRQFSTLVSTSRTMRLCCLGLCKPKIVHSNWNILNNFHNRMQSTDIIRYLFQDAFIFKSDVGFQTKGISTLTALRIERLLYAKRLFFDSKQSLVPVDKSDDELKKVNLNHEVSNEDVLTKETKPNRISSRKLSEECNSLSDVLDAFSKAPTFPSSNYFTAMWTIAKRLSDDQKRFEKRLMFSHPAFNQLCEHMMREAKIMQYKYLLFSLHAIVKLGIPQNTILVQTLLRVTQERINECDEICLSVLSTVLEAMEPCKNVHVLRTGFRILVDQQVWKIEDVFTLQVVMKCIGKDAPIALKRKLEMKALRELDRFSVLNSQHMFEVLAAMNHRSLILLDECSKVVLDNIHGCPLRIMINILQSCKDLQYHNLDLFKGLADYVAATFDIWKFRKVLFILILFENLGFRPVGLMDLFMKRIVEDPESLNMKNILSILHTYSSLNHVYKCQNKEQFVEVMASALTGYLHTISSENLLDAVYSFCLMNYFPLAPFNQLLQKDIISELLTSDDMKNAYKLHTLDTCLKLDDTVYLRDIALSLPQLPRELPSSHTNAKVAEVLSSLLGGEGHFSKDVHLPHNYHIDFEIRMDTNRNQVLPLSDVDTTSATDIQRVAVLCVSRSAYCLGSSHPRGFLAMKMRHLNAMGFHVILVNNWEMDKLEMEDAVTFLKTKIYSVEALPVAAVNVQSTQ
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9NYY8 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S86 | Phosphorylation | Uniprot | |
| T92 | Phosphorylation | Uniprot | |
| K93 | Ubiquitination | Uniprot | |
| K125 | Ubiquitination | Uniprot | |
| S126 | Phosphorylation | Uniprot | |
| K132 | Ubiquitination | Uniprot | |
| S140 | Phosphorylation | Uniprot | |
| K147 | Ubiquitination | Uniprot | |
| K158 | Ubiquitination | Uniprot | |
| S160 | Phosphorylation | Uniprot | |
| S167 | Phosphorylation | Uniprot | |
| S174 | Phosphorylation | Uniprot | |
| S181 | Phosphorylation | Uniprot | |
| K200 | Ubiquitination | Uniprot | |
| Y229 | Phosphorylation | Uniprot | |
| K326 | Ubiquitination | Uniprot | |
| C377 | S-Nitrosylation | Uniprot | |
| S388 | Phosphorylation | Uniprot | |
| Y394 | Phosphorylation | Uniprot | |
| Y406 | Phosphorylation | Uniprot | |
| K535 | Ubiquitination | Uniprot | |
| S621 | Phosphorylation | Uniprot | |
| T687 | Phosphorylation | Uniprot | |
| K690 | Ubiquitination | Uniprot | |
| K692 | Ubiquitination | Uniprot | |
| S708 | Phosphorylation | Uniprot |
Research Backgrounds
Plays an important role in assembly of the mitochondrial large ribosomal subunit. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation.
Mitochondrion matrix>Mitochondrion nucleoid.
Note: Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids.
Expression detected in spleen, thymus, testis, ovary, colon, heart, smooth muscle, kidney, brain, lung, liver and white adipose tissue with highest expression in heart, smooth muscle and thyroid.
Monomer. Found in a complex with GRSF1, DDX28, DHX30 and FASTKD5. Associates with the 16S mitochondrial rRNA (16S mt-rRNA). Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA.
Belongs to the FAST kinase family.
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