SmD3 Antibody - #DF8806
| Product: | SmD3 Antibody |
| Catalog: | DF8806 |
| Description: | Rabbit polyclonal antibody to SmD3 |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 14 kDa; 14kD(Calculated). |
| Uniprot: | P62318 |
| RRID: | AB_2842003 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8806, RRID:AB_2842003.
Fold/Unfold
Sm D3; Sm-D3; small nuclear ribonucleoprotein D3 polypeptide 18kDa; Small nuclear ribonucleoprotein Sm D3; SmD3; SMD3_HUMAN; snRNP core protein D3; SNRPD3;
Immunogens
A synthesized peptide derived from human SmD3, corresponding to a region within the internal amino acids.
- P62318 SMD3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSIGVPIKVLHEAEGHIVTCETNTGEVYRGKLIEAEDNMNCQMSNITVTYRDGRVAQLEQVYIRGSKIRFLILPDMLKNAPMLKSMKNKNQGSGAGRGKAAILKAQVAARGRGRGMGRGNIFQKRR
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
Research Backgrounds
Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity).
Methylated on arginine residues by PRMT5 and PRMT7; probable asymmetric dimethylation which is required for assembly and biogenesis of snRNPs.
Cytoplasm>Cytosol. Nucleus.
Note: SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
Belongs to the snRNP core protein family.
Research Fields
· Genetic Information Processing > Transcription > Spliceosome.
· Human Diseases > Immune diseases > Systemic lupus erythematosus.
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