SDCCAG8 Antibody - #DF8846
| Product: | SDCCAG8 Antibody |
| Catalog: | DF8846 |
| Description: | Rabbit polyclonal antibody to SDCCAG8 |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Mol.Wt.: | 83 kDa; 83kD(Calculated). |
| Uniprot: | Q86SQ7 |
| RRID: | AB_2842043 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8846, RRID:AB_2842043.
Fold/Unfold
Antigen NY CO 8; Antigen NY-CO-8; BBS16; CCCAP; CCCAP SLSN7; Centrosomal colon cancer autoantigen protein; hCCCAP; HSPC085; NPHP10; NPHP10 gene; NY-CO-8; Sdccag8; SDCG8_HUMAN; Serologically defined colon cancer antigen 8; Serologically defined colon cancer antigen 8 homolog; SLSN7; SLSN7 gene;
Immunogens
Expressed in thymus, prostate, testis, ovary, small intestine, colon, mucosa, colon and renal cancer tumors.
- Q86SQ7 SDCG8_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAKSPENSTLEEILGQYQRSLREHASRSIHQLTCALKEGDVTIGEDAPNLSFSTSVGNEDARTAWPELQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQLPSMPQSDC
PTMs - Q86SQ7 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S4 | Phosphorylation | Uniprot | |
| S28 | Phosphorylation | Uniprot | |
| S51 | Phosphorylation | Uniprot | |
| S71 | Phosphorylation | Uniprot | |
| K78 | Ubiquitination | Uniprot | |
| S89 | Phosphorylation | Uniprot | |
| S92 | Phosphorylation | Uniprot | |
| S94 | Phosphorylation | Uniprot | |
| S100 | Phosphorylation | Uniprot | |
| K140 | Ubiquitination | Uniprot | |
| K165 | Ubiquitination | Uniprot | |
| K203 | Ubiquitination | Uniprot | |
| K215 | Ubiquitination | Uniprot | |
| K229 | Ubiquitination | Uniprot | |
| T231 | Phosphorylation | Uniprot | |
| Y232 | Phosphorylation | Uniprot | |
| K235 | Ubiquitination | Uniprot | |
| K261 | Ubiquitination | Uniprot | |
| K341 | Ubiquitination | Uniprot | |
| K394 | Acetylation | Uniprot | |
| K395 | Methylation | Uniprot | |
| K399 | Methylation | Uniprot | |
| K429 | Ubiquitination | Uniprot | |
| K513 | Ubiquitination | Uniprot | |
| S544 | Phosphorylation | Uniprot | |
| S550 | Phosphorylation | Uniprot | |
| T568 | Phosphorylation | Uniprot | |
| K616 | Ubiquitination | Uniprot | |
| Y630 | Phosphorylation | Uniprot | |
| S711 | Phosphorylation | Uniprot |
Research Backgrounds
Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). Plays also an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis.
Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome>Centriole. Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome. Cytoplasm>Cytoskeleton>Cilium basal body. Cell junction.
Note: Located at the distal ends of both centrioles and colocalizes to centrosomes throughout the cell cycle.
Cytoplasm.
Expressed in thymus, prostate, testis, ovary, small intestine, colon, mucosa, colon and renal cancer tumors.
Homodimer (By similarity). Interacts with OFD1; the interaction is direct. Interacts with FAM161A. Interacts with RABEP2, ERC1 and CEP131.
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