MAST1 Antibody - #DF8892

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Product: MAST1 Antibody
Catalog: DF8892
Description: Rabbit polyclonal antibody to MAST1
Application: WB
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog
Mol.Wt.: 171kDa; 171kD(Calculated).
Uniprot: Q9Y2H9
RRID: AB_2842088

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 100ul $280 In stock
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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(91%), Bovine(91%), Horse(80%), Sheep(91%), Rabbit(90%), Dog(91%)
Clonality:
Polyclonal
Specificity:
MAST1 Antibody detects endogenous levels of total MAST1.
RRID:
AB_2842088
Cite Format: Affinity Biosciences Cat# DF8892, RRID:AB_2842088.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

9430008B02Rik; KIAA0973; MAST 1; MAST1; MAST1_HUMAN; Microtubule associated serine/threonine kinase 1; Microtubule associated serine/threonine protein kinase 1; Microtubule-associated serine/threonine-protein kinase 1; SAST 124; SAST 170; SAST; SAST170; Syntrophin associated serine/threonine kinase; Syntrophin associated serine/threonine protein kinase; Syntrophin-associated serine/threonine-protein kinase;

Immunogens

Immunogen:
Uniprot:

Q9Y2H9(MAST1_HUMAN) >>Visit HPA database.

Gene(ID):
MAST1(22983)
Expression:
Q9Y2H9 MAST1_HUMAN:

Expressed in fetal brain.

Sequence:
MSDSLWTALSNFSMPSFPGGSMFRRTKSCRTSNRKSLILTSTSPTLPRPHSPLPGHLGSSPLDSPRNFSPNTPAHFSFASSRRADGRRWSLASLPSSGYGTNTPSSTVSSSCSSQERLHQLPYQPTVDELHFLSKHFGSTESITDEDGGRRSPAVRPRSRSLSPGRSPSSYDNEIVMMNHVYKERFPKATAQMEEKLRDFTRAYEPDSVLPLADGVLSFIHHQIIELARDCLTKSRDGLITTVYFYELQENLEKLLQDAYERSESLEVAFVTQLVKKLLIIISRPARLLECLEFNPEEFYHLLEAAEGHAKEGHLVKTDIPRYIIRQLGLTRDPFPDVVHLEEQDSGGSNTPEQDDLSEGRSSKAKKPPGENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKAEFIPHLESEDDTSYFDTRSDRYHHVNSYDEDDTTEEEPVEIRQFSSCSPRFSKVYSSMEQLSQHEPKTPVAAAGSSKREPSTKGPEEKVAGKREGLGGLTLREKTWRGGSPEIKRFSASEASFLEGEASPPLGARRRFSALLEPSRFSAPQEDEDEARLRRPPRPSSDPAGSLDARAPKEETQGEGTSSAGDSEATDRPRPGDLCPPSKDGDASGPRATNDLVLRRARHQQMSGDVAVEKRPSRTGGKVIKSASATALSVMIPAVDPHGSSPLASPMSPRSLSSNPSSRDSSPSRDYSPAVSGLRSPITIQRSGKKYGFTLRAIRVYMGDTDVYSVHHIVWHVEEGGPAQEAGLCAGDLITHVNGEPVHGMVHPEVVELILKSGNKVAVTTTPFENTSIRIGPARRSSYKAKMARRNKRPSAKEGQESKKRSSLFRKITKQSNLLHTSRSLSSLNRSLSSSDSLPGSPTHGLPARSPTHSYRSTPDSAYLGASSQSSSPASSTPNSPASSASHHIRPSTLHGLSPKLHRQYRSARCKSAGNIPLSPLAHTPSPTQASPPPLPGHTVGSSHTTQSFPAKLHSSPPVVRPRPKSAEPPRSPLLKRVQSAEKLGASLSADKKGALRKHSLEVGHPDFRKDFHGELALHSLAESDGETPPVEGLGAPRQVAVRRLGRQESPLSLGADPLLPEGASRPPVSSKEKESPGGAEACTPPRATTPGGRTLERDVGCTRHQSVQTEDGTGGMARAVAKAALSPVQEHETGRRSSSGEAGTPLVPIVVEPARPGAKAVVPQPLGADSKGLQEPAPLAPSVPEAPRGRERWVLEVVEERTTLSGPRSKPASPKLSPEPQTPSLAPAKCSAPSSAVTPVPPASLLGSGTKPQVGLTSRCPAEAVPPAGLTKKGVSSPAPPGP

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
91
Bovine
91
Sheep
91
Dog
91
Rabbit
90
Horse
80
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9Y2H9 As Substrate

Site PTM Type Enzyme
T45 Phosphorylation
S51 Phosphorylation
S64 Phosphorylation
S69 Phosphorylation
T103 Phosphorylation
S139 Phosphorylation
T140 Phosphorylation
S142 Phosphorylation
T144 Phosphorylation
S152 Phosphorylation
S159 Phosphorylation
S161 Phosphorylation
S163 Phosphorylation
Y182 Phosphorylation
K188 Ubiquitination
Y204 Phosphorylation
S283 Phosphorylation
K317 Ubiquitination
Y323 Phosphorylation
K366 Ubiquitination
K407 Ubiquitination
S519 Phosphorylation
K545 Ubiquitination
S708 Phosphorylation
T728 Phosphorylation
S736 Phosphorylation
R767 Methylation
S782 Phosphorylation
S789 Phosphorylation
S799 Phosphorylation
S832 Phosphorylation
K908 Ubiquitination
S919 Phosphorylation
S1110 Phosphorylation
S1113 Phosphorylation
S1184 Phosphorylation
S1252 Phosphorylation
S1258 Phosphorylation
K1262 Methylation
S1351 Phosphorylation
S1356 Phosphorylation
S1357 Phosphorylation
S1413 Phosphorylation
S1426 Phosphorylation
T1431 Phosphorylation
S1500 Phosphorylation
S1504 Phosphorylation

Research Backgrounds

Function:

Microtubule-associated protein essential for correct brain development. Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity).

Subcellular Location:

Cell membrane>Peripheral membrane protein>Cytoplasmic side. Cytoplasm>Cytoskeleton. Cell projection>Axon. Cell projection>Dendrite.
Note: Also localized in the soma of neurons. Observed as punctate clusters in the processes of interneurons and along the cell body periphery. Colocalizes with syntrophins at the cell membrane.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in fetal brain.

Subunit Structure:

Interacts with the microtubules. Part of a low affinity complex that associates with, but is distinct from, the postsynaptic density. Interacts with SNTB2.

Family&Domains:

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

References

1). Hypoxia caused by unilateral nasal obstruction decreases mandibular density in rats through inhibition of Cyp1a1 expression. Journal of Oral Pathology & Medicine, 2023 (PubMed: 37489271) [IF=2.7]

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