CDCA7L Antibody - #DF8916
| Product: | CDCA7L Antibody |
| Catalog: | DF8916 |
| Description: | Rabbit polyclonal antibody to CDCA7L |
| Application: | WB IHC |
| Reactivity: | Human |
| Prediction: | Pig, Sheep |
| Mol.Wt.: | 52 kDa; 52kD(Calculated). |
| Uniprot: | Q96GN5 |
| RRID: | AB_2842112 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8916, RRID:AB_2842112.
Fold/Unfold
c Myc Interacting protein JPO2; CDCA7L; DKFZp762L0311; HR1; JPO2; Protein JPO2; R1; RAM2; Transcription Factor RAM2;
Immunogens
- Q96GN5 CDA7L_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MELATRYQIPKEVADIFNAPSDDEEFVGFRDDVPMETLSSEESCDSFDSLESGKQQDVRFHSKYFTEELRRIFIEDTDSETEDFAGFTQSDLNGKTNPEVMVVESDLSDDGKASLVSEEEEDEEEDKATPRRSRSRRSSIGLRVAFQFPTKKLANKPDKNSSSEQLFSSARLQNEKKTILERKKDCRQVIQREDSTSESEDDSRDESQESSDALLKRTMNIKENKAMLAQLLAELNSMPDFFPVRTPTSASRKKTVRRAFSEGQITRRMNPTRSARPPEKFALENFTVSAAKFAEEFYSFRRRKTIGGKCREYRRRHRISSFRPVEDITEEDLENVAITVRDKIYDKVLGNTCHQCRQKTIDTKTVCRNQGCCGVRGQFCGPCLRNRYGEDVRSALLDPDWVCPPCRGICNCSYCRKRDGRCATGILIHLAKFYGYDNVKEYLESLQKELVEDN
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q96GN5 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S21 | Phosphorylation | Uniprot | |
| S40 | Phosphorylation | Uniprot | |
| S43 | Phosphorylation | Uniprot | |
| S46 | Phosphorylation | Uniprot | |
| S52 | Phosphorylation | Uniprot | |
| S62 | Phosphorylation | Uniprot | |
| K63 | Sumoylation | Uniprot | |
| K63 | Ubiquitination | Uniprot | |
| T77 | Phosphorylation | Uniprot | |
| S79 | Phosphorylation | Uniprot | |
| T81 | Phosphorylation | Uniprot | |
| S105 | Phosphorylation | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| S114 | Phosphorylation | Uniprot | |
| S117 | Phosphorylation | Uniprot | |
| T129 | Phosphorylation | Uniprot | |
| S135 | Phosphorylation | Uniprot | |
| S138 | Phosphorylation | Uniprot | |
| S139 | Phosphorylation | Uniprot | |
| K151 | Acetylation | Uniprot | |
| K151 | Sumoylation | Uniprot | |
| K156 | Sumoylation | Uniprot | |
| K159 | Sumoylation | Uniprot | |
| K159 | Ubiquitination | Uniprot | |
| S162 | Phosphorylation | Uniprot | |
| S163 | Phosphorylation | Uniprot | |
| S168 | Phosphorylation | Uniprot | |
| S169 | Phosphorylation | Uniprot | |
| K176 | Ubiquitination | Uniprot | |
| K177 | Sumoylation | Uniprot | |
| K177 | Ubiquitination | Uniprot | |
| S195 | Phosphorylation | Uniprot | |
| T196 | Phosphorylation | Uniprot | |
| S197 | Phosphorylation | Uniprot | |
| S199 | Phosphorylation | Uniprot | |
| S207 | Phosphorylation | Uniprot | |
| K222 | Ubiquitination | Uniprot | |
| K225 | Sumoylation | Uniprot | |
| S237 | Phosphorylation | Uniprot | |
| T246 | Phosphorylation | Uniprot | |
| T248 | Phosphorylation | Uniprot | |
| S249 | Phosphorylation | Uniprot | |
| S261 | Phosphorylation | Uniprot | |
| K280 | Sumoylation | Uniprot | |
| K280 | Ubiquitination | Uniprot | |
| S299 | Phosphorylation | Uniprot | |
| S320 | Phosphorylation | Uniprot | |
| S321 | Phosphorylation | Uniprot | |
| Y345 | Phosphorylation | Uniprot | |
| K347 | Sumoylation | Uniprot | |
| K347 | Ubiquitination | Uniprot | |
| K359 | Ubiquitination | Uniprot | |
| K364 | Sumoylation | Uniprot | |
| K364 | Ubiquitination | Uniprot | |
| R393 | Methylation | Uniprot | |
| R407 | Methylation | Uniprot | |
| T424 | Phosphorylation | Uniprot | |
| K432 | Ubiquitination | Uniprot | |
| K440 | Ubiquitination | Uniprot | |
| K448 | Ubiquitination | Uniprot |
Research Backgrounds
Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.
Phosphorylation increases its interaction with PSIP1.
Cytoplasm. Nucleus.
Note: Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.
Ubiquitous. Overexpressed in medulloblastoma.
Interacts with MYC. Interacts (via IBM motifs) with PSIP1 (via IBD domain); phosphorylation increases its affinity for PSIP1.
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