IL10RB Antibody - #DF8957
| Product: | IL10RB Antibody |
| Catalog: | DF8957 |
| Description: | Rabbit polyclonal antibody to IL10RB |
| Application: | WB |
| Reactivity: | Human |
| Prediction: | Horse |
| Mol.Wt.: | 37 kDa, 45 kDa; 37kD(Calculated). |
| Uniprot: | Q08334 |
| RRID: | AB_2842153 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8957, RRID:AB_2842153.
Fold/Unfold
Cd210; CDw210b; CRF2 4; CRF2-4; CRFB4; Cytokine receptor class II; Cytokine receptor class II CRF2 4; Cytokine receptor class-II member 4; Cytokine receptor family 2 member 4; Cytokine receptor family II member 4; D21S58; D21S66; I10R2_HUMAN; IL-10 receptor subunit beta; IL-10R subunit 2; IL-10R subunit beta; IL-10R2; IL-10RB; IL10R2; IL10RB; Interleukin 10 receptor beta; Interleukin-10 receptor subunit 2; Interleukin-10 receptor subunit beta;
Immunogens
- Q08334 I10R2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAWSLGSWLGGCLLVSALGMVPPPENVRMNSVNFKNILQWESPAFAKGNLTFTAQYLSYRIFQDKCMNTTLTECDFSSLSKYGDHTLRVRAEFADEHSDWVNITFCPVDDTIIGPPGMQVEVLADSLHMRFLAPKIENEYETWTMKNVYNSWTYNVQYWKNGTDEKFQITPQYDFEVLRNLEPWTTYCVQVRGFLPDRNKAGEWSEPVCEQTTHDETVPSWMVAVILMASVFMVCLALLGCFALLWCVYKKTKYAFSPRNSLPQHLKEFLGHPHHNTLLFFSFPLSDENDVFDKLSVIAEDSESGKQNPGDSCSLGTPPGQGPQS
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q08334 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T252 | Phosphorylation | Uniprot | |
| S257 | Phosphorylation | Uniprot | |
| S261 | Phosphorylation | Uniprot | |
| S296 | Phosphorylation | Uniprot | |
| S302 | Phosphorylation | Uniprot | |
| S314 | Phosphorylation | Uniprot | |
| T317 | Phosphorylation | Uniprot |
Research Backgrounds
Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.
Membrane>Single-pass type I membrane protein.
Heterodimer with IFNLR1.
Belongs to the type II cytokine receptor family.
Research Fields
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Parasitic > Toxoplasmosis.
· Human Diseases > Infectious diseases: Bacterial > Tuberculosis.
· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.
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For Research Use Only.
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