CENPP Antibody - #DF9060

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Product: CENPP Antibody
Catalog: DF9060
Description: Rabbit polyclonal antibody to CENPP
Application: WB
Reactivity: Human
Mol.Wt.: 33 kDa; 33kD(Calculated).
Uniprot: Q6IPU0
RRID: AB_2842256

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Related Downloads
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Polyclonal
Specificity:
CENPP Antibody detects endogenous levels of total CENPP.
RRID:
AB_2842256
Cite Format: Affinity Biosciences Cat# DF9060, RRID:AB_2842256.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

CENP P; CENP-P; cenpp; CENPP_HUMAN; Centromere protein P; FLJ33928; RP11-19J3.3;

Immunogens

Immunogen:
Uniprot:

Q6IPU0(CENPP_HUMAN) >>Visit HPA database.

Gene(ID):
CENPP(401541)
Sequence:
MDAELAEVRALQAEIAALRRACEDPPAPWEEKSRVQKSFQAIHQFNLEGWKSSKDLKNQLGHLESELSFLSTLTGINIRNHSKQTEDLTSTEMTEKSIRKVLQRHRLSGNCHMVTFQLEFQILEIQNKERLSSAVTDLNIIMEPTECSELSEFVSRAEERKDLFMFFRSLHFFVEWFEYRKRTFKHLKEKYPDAVYLSEGPSSCSMGIRSASRPGFELVIVWRIQIDEDGKVFPKLDLLTKVPQRALELDKNRAIETAPLSFRTLVGLLGIEAALESLIKSLCAEENN

PTMs - Q6IPU0 As Substrate

Site PTM Type Enzyme
K32 Ubiquitination
K37 Ubiquitination
S38 Phosphorylation
K83 Ubiquitination
T85 Phosphorylation
T89 Phosphorylation
T94 Phosphorylation
K96 Ubiquitination
K241 Ubiquitination
K251 Ubiquitination
T257 Phosphorylation
S261 Phosphorylation

Research Backgrounds

Function:

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.

Subcellular Location:

Nucleus. Chromosome>Centromere.
Note: Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU.

Family&Domains:

Belongs to the CENP-P/CTF19 family.

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
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