NFKBIL1 Antibody - #DF9066
| Product: | NFKBIL1 Antibody |
| Catalog: | DF9066 |
| Description: | Rabbit polyclonal antibody to NFKBIL1 |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 43 kDa; 43kD(Calculated). |
| Uniprot: | Q9UBC1 |
| RRID: | AB_2842262 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9066, RRID:AB_2842262.
Fold/Unfold
I-kappa-B-like protein; IkappaBL; IKBL; IKBL1_HUMAN; Inhibitor of kappa B-like protein; LST1; NF-kappa-B inhibitor-like protein 1; NFKBIL; Nfkbil1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1;
Immunogens
Detected in different cell types including monocytes, T-cells, B-cells and hepatocytes.
- Q9UBC1 IKBL1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSNPSPQVPEEEASTSVCRPKSSMASTSRRQRRERRFRRYLSAGRLVRAQALLQRHPGLDVDAGQPPPLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQGPDAYTDFFLPLLSRCPSAMGIKNKDGETPGQILGWGPPWDSAEEEEEDDASKEREWRQKLQGELEDEWQEVMGRFEGDASHETQEPESFSAWSDRLAREHAQKCQQQQREAEGSCRPPRAEGSSQSWRQQEEEQRLFRERARAKEEELRESRARRAQEALGDREPKPTRAGPREEHPRGAGRGSLWRFGDVPWPCPGGGDPEAMAAALVARGPPLEEQGALRRYLRVQQVRWHPDRFLQRFRSQIETWELGRVMGAVTALSQALNRHAEALK
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9UBC1 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Phosphorylation | Uniprot | |
| S5 | Phosphorylation | Uniprot | |
| S26 | Phosphorylation | Uniprot | |
| T27 | Phosphorylation | Uniprot | |
| S28 | Phosphorylation | Uniprot | |
| S150 | Phosphorylation | Uniprot | |
| K212 | Ubiquitination | Uniprot | |
| K253 | Acetylation | Uniprot | |
| R291 | Methylation | Uniprot | |
| S352 | Phosphorylation | Uniprot | |
| T367 | Phosphorylation | Uniprot |
Research Backgrounds
Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli.
Nucleus.
Note: Nuclear localization with a speckled expression pattern in some cells. Colocalizes with CACTIN in the nucleus.
Detected in different cell types including monocytes, T-cells, B-cells and hepatocytes.
Interacts with CACTIN (via N-terminal domain); the interaction occurs in a proinflammatory-independent manner.
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