ALKBH7 Antibody - #DF9074
| Product: | ALKBH7 Antibody |
| Catalog: | DF9074 |
| Description: | Rabbit polyclonal antibody to ALKBH7 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse, Monkey |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 24 kDa; 25kD(Calculated). |
| Uniprot: | Q9BT30 |
| RRID: | AB_2842270 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9074, RRID:AB_2842270.
Fold/Unfold
ABH7; ALKB7_HUMAN; ALKBH7; Alkylated DNA repair protein alkB homolog 7; MGC10974; Probable alpha-ketoglutarate-dependent dioxygenase ABH7; SPATA11; Spermatogenesis cell proliferation-related protein; Spermatogenesis-associated protein 11; UNQ6002; UNQ6002/PRO34564;
Immunogens
Widely expressed, with highest expression in pancreas, followed by spleen, prostate, ovary and placenta.
- Q9BT30 ALKB7_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGTGLLALRTLPGPSWVRGSGPSVLSRLQDAAVVRPGFLSTAEEETLSRELEPELRRRRYEYDHWDAAIHGFRETEKSRWSEASRAILQRVQAAAFGPGQTLLSSVHVLDLEARGYIKPHVDSIKFCGATIAGLSLLSPSVMRLVHTQEPGEWLELLLEPGSLYILRGSARYDFSHEILRDEESFFGERRIPRGRRISVICRSLPEGMGPGESGQPPPAC
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
Research Backgrounds
May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism (By similarity).
Mitochondrion matrix.
Widely expressed, with highest expression in pancreas, followed by spleen, prostate, ovary and placenta.
Monomer.
Belongs to the alkB family.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.