ALMS1 Antibody - #DF9197

(1)  
Product: ALMS1 Antibody
Catalog: DF9197
Description: Rabbit polyclonal antibody to ALMS1
Application: WB IHC
Reactivity: Human, Rat
Prediction: Xenopus
Mol.Wt.: 461kDa, 200 kDa; 461kD(Calculated).
Uniprot: Q8TCU4
RRID: AB_2842393

View similar products>>

   Size Price Inventory
 100ul $280 In stock
 200ul $350 In stock

Lead Time: Same day delivery

For pricing and ordering contact:
Local distributors
Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Rat
Prediction:
Xenopus(80%)
Clonality:
Polyclonal
Specificity:
ALMS1 Antibody detects endogenous levels of total ALMS1.
RRID:
AB_2842393
Cite Format: Affinity Biosciences Cat# DF9197, RRID:AB_2842393.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Alms1; ALMS1_HUMAN; ALSS; Alstrom syndrome 1; Alstrom syndrome protein 1;

Immunogens

Immunogen:
Uniprot:

Q8TCU4(ALMS1_HUMAN) >>Visit HPA database.

Gene(ID):
ALMS1(7840)
Expression:
Q8TCU4 ALMS1_HUMAN:

Expressed in all tissues tested including adipose and pancreas. Expressed by beta-cells of the islets in the pancreas (at protein level).

Sequence:
MEPEDLPWPGELEEEEEEEEEEEEEEEEAAAAAAANVDDVVVVEEVEEEAGRELDSDSHYGPQHLESIDDEEDEEAKAWLQAHPGRILPPLSPPQHRYSEGERTSLEKIVPLTCHVWQQIVYQGNSRTQISDTNVVCLETTAQRGSGDDQKTESWHCLPQEMDSSQTLDTSQTRFNVRTEDTEVTDFPSLEEGILTQSENQVKEPNRDLFCSPLLVIQDSFASPDLPLLTCLTQDQEFAPDSLFHQSELSFAPLRGIPDKSEDTEWSSRPSEVSEALFQATAEVASDLASSRFSVSQHPLIGSTAVGSQCPFLPSEQGNNEETISSVDELKIPKDCDRYDDLCSYMSWKTRKDTQWPENNLADKDQVSVATSFDITDENIATKRSDHFDAARSYGQYWTQEDSSKQAETYLTKGLQGKVESDVITLDGLNENAVVCSERVAELQRKPTRESEYHSSDLRMLRMSPDTVPKAPKHLKAGDTSKGGIAKVTQSNLKSGITTTPVDSDIGSHLSLSLEDLSQLAVSSPLETTTGQHTDTLNQKTLADTHLTEETLKVTAIPEPADQKTATPTVLSSSHSHRGKPSIFYQQGLPDSHLTEEALKVSAAPGLADQTTGMSTLTSTSYSHREKPGTFYQQELPESNLTEEPLEVSAAPGPVEQKTGIPTVSSTSHSHVEDLLFFYRQTLPDGHLTDQALKVSAVSGPADQKTGTATVLSTPHSHREKPGIFYQQEFADSHQTEETLTKVSATPGPADQKTEIPAVQSSSYSQREKPSILYPQDLADSHLPEEGLKVSAVAGPADQKTGLPTVPSSAYSHREKLLVFYQQALLDSHLPEEALKVSAVSGPADGKTGTPAVTSTSSASSSLGEKPSAFYQQTLPNSHLTEEALKVSIVPGPGDQKTGIPSAPSSFYSHREKPIIFSQQTLPDFLFPEEALKVSAVSVLAAQKTGTPTVSSNSHSHSEKSSVFYQQELPDSDLPRESLKMSAIPGLTDQKTVPTPTVPSGSFSHREKPSIFYQQEWPDSYATEKALKVSTGPGPADQKTEIPAVQSSSYPQREKPSVLYPQVLSDSHLPEESLKVSAFPGPADQMTDTPAVPSTFYSQREKPGIFYQQTLPESHLPKEALKISVAPGLADQKTGTPTVTSTSYSQHREKPSIFHQQALPGTHIPEEAQKVSAVTGPGNQKTWIPRVLSTFYSQREKPGIFYQQTLPGSHIPEEAQKVSPVLGPADQKTGTPTPTSASYSHTEKPGIFYQQVLPDNHPTEEALKISVASEPVDQTTGTPAVTSTSYSQYREKPSIFYQQSLPSSHLTEEAKNVSAVPGPADQKTVIPILPSTFYSHTEKPGVFYQQVLPHSHPTEEALKISVASEPVDQTTGTPTVTSTSYSQHTEKPSIFYQQSLPGSHLTEEAKNVSAVPGPGDRKTGIPTLPSTFYSHTEKPGSFYQQVLPHSHLPEEALEVSVAPGPVDQTIGTPTVTSPSSSFGEKPIVIYKQAFPEGHLPEESLKVSVAPGPVGQTTGAPTITSPSYSQHRAKSGSFYQLALLGSQIPEEALRVSSAPGPADQTTGIPTITSTSYSFGEKPIVNYKQAFPDGHLPEEALKVSIVSGPTEKKTDIPAGPLGSSALGEKPITFYRQALLDSPLNKEVVKVSAAPGPADQKTETLPVHSTSYSNRGKPVIFYQQTLSDSHLPEEALKVPPVPGPDAQKTETPSVSSSLYSYREKPIVFYQQALPDSELTQEALKVSAVPQPADQKTGLSTVTSSFYSHTEKPNISYQQELPDSHLTEEALKVSNVPGPADQKTGVSTVTSTSYSHREKPIVSYQRELPHFTEAGLKILRVPGPADQKTGINILPSNSYPQREHSVISYEQELPDLTEVTLKAIGVPGPADQKTGIQIASSSSYSNREKASIFHQQELPDVTEEALNVFVVPGQGDRKTEIPTVPLSYYSRREKPSVISQQELPDSHLTEEALKVSPVSIPAEQKTGIPIGLSSSYSHSHKEKLKISTVHIPDDQKTEFPAATLSSYSQIEKPKISTVIGPNDQKTPSQTAFHSSYSQTVKPNILFQQQLPDRDQSKGILKISAVPELTDVNTGKPVSLSSSYFHREKSNIFSPQELPGSHVTEDVLKVSTIPGPAGQKTVLPTALPSSFSHREKPDIFYQKDLPDRHLTEDALKISSALGQADQITGLQTVPSGTYSHGENHKLVSEHVQRLIDNLNSSDSSVSSNNVLLNSQADDRVVINKPESAGFRDVGSEEIQDAENSAKTLKEIRTLLMEAENMALKRCNFPAPLARFRDISDISFIQSKKVVCFKEPSSTGVSNGDLLHRQPFTEESPSSRCIQKDIGTQTNLKCRRGIENWEFISSTTVRSPLQEAESKVSMALEETLRQYQAAKSVMRSEPEGCSGTIGNKIIIPMMTVIKSDSSSDASDGNGSCSWDSNLPESLESVSDVLLNFFPYVSPKTSITDSREEEGVSESEDGGGSSVDSLAAHVKNLLQCESSLNHAKEILRNAEEEESRVRAHAWNMKFNLAHDCGYSISELNEDDRRKVEEIKAELFGHGRTTDLSKGLQSPRGMGCKPEAVCSHIIIESHEKGCFRTLTSEHPQLDRHPCAFRSAGPSEMTRGRQNPSSCRAKHVNLSASLDQNNSHFKVWNSLQLKSHSPFQNFIPDEFKISKGLRMPFDEKMDPWLSELVEPAFVPPKEVDFHSSSQMPSPEPMKKFTTSITFSSHRHSKCISNSSVVKVGVTEGSQCTGASVGVFNSHFTEEQNPPRDLKQKTSSPSSFKMHSNSQDKEVTILAEGRRQSQKLPVDFERSFQEEKPLERSDFTGSHSEPSTRANCSNFKEIQISDNHTLISMGRPSSTLGVNRSSSRLGVKEKNVTITPDLPSCIFLEQRELFEQSKAPRADDHVRKHHSPSPQHQDYVAPDLPSCIFLEQRELFEQCKAPYVDHQMRENHSPLPQGQDSIASDLPSPISLEQCQSKAPGVDDQMNKHHFPLPQGQDCVVEKNNQHKPKSHISNINVEAKFNTVVSQSAPNHCTLAASASTPPSNRKALSCVHITLCPKTSSKLDSGTLDERFHSLDAASKARMNSEFNFDLHTVSSRSLEPTSKLLTSKPVAQDQESLGFLGPKSSLDFQVVQPSLPDSNTITQDLKTIPSQNSQIVTSRQIQVNISDFEGHSNPEGTPVFADRLPEKMKTPLSAFSEKLSSDAVTQITTESPEKTLFSSEIFINAEDRGHEIIEPGNQKLRKAPVKFASSSSVQQVTFSRGTDGQPLLLPYKPSGSTKMYYVPQLRQIPPSPDSKSDTTVESSHSGSNDAIAPDFPAQVLGTRDDDLSATVNIKHKEGIYSKRVVTKASLPVGEKPLQNENADASVQVLITGDENLSDKKQQEIHSTRAVTEAAQAKEKESLQKDTADSSAAAAAEHSAQVGDPEMKNLPDTKAITQKEEIHRKKTVPEEAWPNNKESLQINIEESECHSEFENTTRSVFRSAKFYIHHPVHLPSDQDICHESLGKSVFMRHSWKDFFQHHPDKHREHMCLPLPYQNMDKTKTDYTRIKSLSINVNLGNKEVMDTTKSQVRDYPKHNGQISDPQRDQKVTPEQTTQHTVSLNELWNKYRERQRQQRQPELGDRKELSLVDRLDRLAKILQNPITHSLQVSESTHDDSRGERSVKEWSGRQQQRNKLQKKKRFKSLEKSHKNTGELKKSKVLSHHRAGRSNQIKIEQIKFDKYILSKQPGFNYISNTSSDCRPSEESELLTDTTTNILSGTTSTVESDILTQTDREVALHERSSSVSTIDTARLIQAFGHERVCLSPRRIKLYSSITNQQRRYLEKRSKHSKKVLNTGHPLVTSEHTRRRHIQVANHVISSDSISSSASSFLSSNSTFCNKQNVHMLNKGIQAGNLEIVNGAKKHTRDVGITFPTPSSSEAKLEENSDVTSWSEEKREEKMLFTGYPEDRKLKKNKKNSHEGVSWFVPVENVESRSKKENVPNTCGPGISWFEPITKTRPWREPLREQNCQGQHLDGRGYLAGPGREAGRDLLRPFVRATLQESLQFHRPDFISRSGERIKRLKLIVQERKLQSMLQTERDALFNIDRERQGHQNRMCPLPKRVFLAIQKNKPISKKEMIQRSKRIYEQLPEVQKKREEEKRKSEYKSYRLRAQLYKKRVTNQLLGRKVPWD

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Xenopus
80
Pig
56
Chicken
43
Horse
0
Bovine
0
Sheep
0
Dog
0
Zebrafish
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q8TCU4 As Substrate

Site PTM Type Enzyme
S92 Phosphorylation
T152 Phosphorylation
S189 Phosphorylation
Y339 Phosphorylation
S344 Phosphorylation
Y345 Phosphorylation
K349 Ubiquitination
S393 Phosphorylation
Y394 Phosphorylation
Y397 Phosphorylation
Y453 Phosphorylation
S464 Phosphorylation
T467 Phosphorylation
K470 Acetylation
K473 Acetylation
K476 Acetylation
S511 Phosphorylation
T567 Phosphorylation
S576 Phosphorylation
Y632 Phosphorylation
S699 Phosphorylation
T706 Phosphorylation
S713 Phosphorylation
T714 Phosphorylation
K721 Ubiquitination
T746 Phosphorylation
T754 Phosphorylation
S763 Phosphorylation
Y764 Phosphorylation
S765 Phosphorylation
K769 Ubiquitination
K800 Ubiquitination
Y811 Phosphorylation
S841 Phosphorylation
K866 Ubiquitination
Y871 Phosphorylation
T881 Phosphorylation
K897 Acetylation
K897 Ubiquitination
K913 Ubiquitination
K960 Ubiquitination
S978 Phosphorylation
K980 Ubiquitination
S982 Phosphorylation
T988 Phosphorylation
T997 Phosphorylation
K1008 Ubiquitination
K1028 Ubiquitination
S1030 Phosphorylation
Y1050 Phosphorylation
K1055 Ubiquitination
Y1060 Phosphorylation
S1067 Phosphorylation
S1073 Phosphorylation
Y1107 Phosphorylation
S1189 Phosphorylation
Y1192 Phosphorylation
S1193 Phosphorylation
S1219 Phosphorylation
Y1249 Phosphorylation
S1269 Phosphorylation
T1275 Phosphorylation
S1285 Phosphorylation
Y1297 Phosphorylation
S1300 Phosphorylation
Y1344 Phosphorylation
Y1392 Phosphorylation
T1519 Phosphorylation
S1530 Phosphorylation
S1532 Phosphorylation
K1623 Acetylation
S1635 Phosphorylation
T1663 Phosphorylation
K1670 Acetylation
Y1712 Phosphorylation
K1717 Ubiquitination
K1811 Ubiquitination
K1829 Ubiquitination
K1840 Ubiquitination
S1857 Phosphorylation
K1874 Ubiquitination
K1930 Ubiquitination
Y1940 Phosphorylation
Y1941 Phosphorylation
S1942 Phosphorylation
K1946 Ubiquitination
S1968 Phosphorylation
K2008 Ubiquitination
K2024 Ubiquitination
K2026 Ubiquitination
K2053 Ubiquitination
K2087 Ubiquitination
K2100 Ubiquitination
S2101 Phosphorylation
K2131 Ubiquitination
S2143 Phosphorylation
K2147 Ubiquitination
K2154 Ubiquitination
K2167 Ubiquitination
K2196 Ubiquitination
K2235 Ubiquitination
S2246 Phosphorylation
S2255 Phosphorylation
K2257 Ubiquitination
K2275 Ubiquitination
K2298 Ubiquitination
K2299 Ubiquitination
K2304 Ubiquitination
S2308 Phosphorylation
K2334 Ubiquitination
K2343 Ubiquitination
T2358 Phosphorylation
K2369 Ubiquitination
K2385 Ubiquitination
K2402 Ubiquitination
T2409 Phosphorylation
S2466 Phosphorylation
K2484 Ubiquitination
S2492 Phosphorylation
K2497 Ubiquitination
K2518 Ubiquitination
K2539 Ubiquitination
K2544 Ubiquitination
K2558 Ubiquitination
K2569 Ubiquitination
R2614 Methylation
K2625 Ubiquitination
S2632 Phosphorylation
S2645 Phosphorylation
K2649 Ubiquitination
S2652 Phosphorylation
K2663 Ubiquitination
K2666 Ubiquitination
R2669 Methylation
K2675 Ubiquitination
S2704 Phosphorylation
T2713 Phosphorylation
K2724 Ubiquitination
S2752 Phosphorylation
T2755 Phosphorylation
T2768 Phosphorylation
S2769 Phosphorylation
K2775 Ubiquitination
S2780 Phosphorylation
K2783 Ubiquitination
S2795 Phosphorylation
K2797 Ubiquitination
S2805 Phosphorylation
K2810 Ubiquitination
T2818 Phosphorylation
K2834 Ubiquitination
K2868 Ubiquitination
T2873 Phosphorylation
K2892 Ubiquitination
K2902 Ubiquitination
K2934 Ubiquitination
S2947 Phosphorylation
S2962 Phosphorylation
S3035 Phosphorylation
T3036 Phosphorylation
S3045 Phosphorylation
K3058 Ubiquitination
T3063 Phosphorylation
S3070 Phosphorylation
K3076 Ubiquitination
K3100 Ubiquitination
K3105 Ubiquitination
S3113 Phosphorylation
K3120 Ubiquitination
S3121 Phosphorylation
S3122 Phosphorylation
S3147 Phosphorylation
S3150 Phosphorylation
T3174 Phosphorylation
K3195 Ubiquitination
S3208 Phosphorylation
K3236 Ubiquitination
S3256 Phosphorylation
K3269 Ubiquitination
K3275 Ubiquitination
Y3277 Phosphorylation
Y3278 Phosphorylation
Y3337 Phosphorylation
K3430 Ubiquitination
K3435 Ubiquitination
K3442 Ubiquitination
K3503 Ubiquitination
S3510 Phosphorylation
K3512 Ubiquitination
K3521 Acetylation
K3521 Ubiquitination
T3538 Phosphorylation
S3549 Phosphorylation
K3564 Ubiquitination
K3572 Ubiquitination
K3585 Ubiquitination
K3604 Ubiquitination
K3621 Ubiquitination
K3661 Ubiquitination
S3681 Phosphorylation
K3710 Sumoylation
K3715 Ubiquitination
S3780 Phosphorylation
S3781 Phosphorylation
S3802 Phosphorylation
S3811 Phosphorylation
K3885 Ubiquitination
K3953 Ubiquitination
S3972 Phosphorylation
T3980 Phosphorylation
K4067 Ubiquitination
K4098 Ubiquitination
K4120 Acetylation
Y4123 Phosphorylation
K4132 Ubiquitination

Research Backgrounds

Function:

Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells.

Subcellular Location:

Cytoplasm. Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome. Cytoplasm>Cytoskeleton>Cilium basal body. Cytoplasm>Cytoskeleton>Spindle pole.
Note: Associated with centrosomes and basal bodies at the base of primary cilia. Specifically locates to the proximal ends of centrioles and basal bodies. Colocalizes partially with NCAPD2 at these sites. During mitosis localizes to both spindle poles.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in all tissues tested including adipose and pancreas. Expressed by beta-cells of the islets in the pancreas (at protein level).

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.