Product: DYNLT3 Antibody
Catalog: DF9474
Description: Rabbit polyclonal antibody to DYNLT3
Application: WB IHC IF/ICC
Reactivity: Human
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus
Mol.Wt.: 13 kDa; 13kD(Calculated).
Uniprot: P51808
RRID: AB_2842670

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 100ul $280 In stock
 200ul $350 In stock

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Product Info

Source:
Rabbit
Application:
WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Prediction:
Pig(91%), Bovine(91%), Horse(82%), Sheep(91%), Rabbit(100%), Dog(91%), Xenopus(82%)
Clonality:
Polyclonal
Specificity:
DYNLT3 Antibody detects endogenous levels of total DYNLT3.
RRID:
AB_2842670
Cite Format: Affinity Biosciences Cat# DF9474, RRID:AB_2842670.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

2310075M16Rik; AU042796; DYLT3_HUMAN; Dynein light chain Tctex-type 3; DYNLT3; Protein 91/23; RP23-256J17.2; RP3; T-complex-associated testis-expressed 1-like; Tcte1l; TCTEX1L;

Immunogens

Immunogen:

A synthesized peptide derived from human DYNLT3, corresponding to a region within N-terminal amino acids.

Uniprot:
Gene(ID):
Sequence:
MEEYHRHCDEVGFNAEEAHNIVKECVDGVLGGEDYNHNNINQWTASIVEQSLTHLVKLGKAYKYIVTCAVVQKSAYGFHTASSCFWDTTSDGTCTVRWENRTMNCIVNVFAIAIVL

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Rabbit
100
Pig
91
Bovine
91
Sheep
91
Dog
91
Horse
82
Xenopus
82
Chicken
70
Zebrafish
64
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

Research Backgrounds

Function:

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity).

Subcellular Location:

Nucleus. Cytoplasm>Cytoskeleton. Chromosome>Centromere>Kinetochore.
Note: Colocalizes with BUB3 at kinetochores specifically during prometaphase.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Family&Domains:

Belongs to the dynein light chain Tctex-type family.

Restrictive clause

 

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For Research Use Only.
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