MRAP Antibody - #DF9621
| Product: | MRAP Antibody |
| Catalog: | DF9621 |
| Description: | Rabbit polyclonal antibody to MRAP |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Mol.Wt.: | 19 kDa; 19kD(Calculated). |
| Uniprot: | Q8TCY5 |
| RRID: | AB_2842817 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9621, RRID:AB_2842817.
Fold/Unfold
B27; C21orf61; FALP; Fat cell-specific low molecular weight protein; Fat tissue-specific low MW protein; FGD2; GCCD2; Melanocortin-2 receptor accessory protein; Mrap; MRAP_HUMAN;
Immunogens
A synthesized peptide derived from human MRAP, corresponding to a region within the internal amino acids.
Expressed in adrenal cortex, testis, breast, thyroid, lymph node, ovary and fat. Expressed in adipose tissues.
- Q8TCY5 MRAP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MANGTNASAPYYSYEYYLDYLDLIPVDEKKLKAHKHSIVIAFWVSLAAFVVLLFLILLYMSWSASPQMRNSPKHHQTCPWSHGLNLHLCIQKCLPCHREPLATSQAQASSVEPGSRTGPDQPLRQESSSTLPLGGFQTHPTLLWELTLNGGPLVRSKPSEPPPGDRTSQLQS
Research Backgrounds
Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells.
Cell membrane>Single-pass membrane protein. Endoplasmic reticulum membrane>Single-pass membrane protein.
Note: The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context (PubMed:20371771). Upon insulin stimulation, it is redistributed into spotty structures throughout the cytoplasm.
Expressed in adrenal cortex, testis, breast, thyroid, lymph node, ovary and fat. Expressed in adipose tissues.
Belongs to the MRAP family.
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