Arrdc4 Antibody - #AF9018
| Product: | Arrdc4 Antibody |
| Catalog: | AF9018 |
| Description: | Rabbit polyclonal antibody to Arrdc4 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Bovine, Horse, Sheep, Dog |
| Mol.Wt.: | 45kDa; 45kD(Calculated). |
| Uniprot: | Q8NCT1 |
| RRID: | AB_2843209 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF9018, RRID:AB_2843209.
Fold/Unfold
ARRD4_HUMAN; ARRDC 4; Arrdc4; Arrestin domain containing protein 4; Arrestin domain-containing protein 4; FLJ36045;
Immunogens
- Q8NCT1 ARRD4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGGEAGCAAAVGAEGRVKSLGLVFEDERKGCYSSGETVAGHVLLEASEPVALRALRLEAQGRATAAWGPSTCPRASASTAALAVFSEVEYLNVRLSLREPPAGEGIILLQPGKHEFPFRFQLPSEPLVTSFTGKYGSIQYCVRAVLERPKVPDQSVKRELQVVSHVDVNTPALLTPVLKTQEKMVGCWFFTSGPVSLSAKIERKGYCNGEAIPIYAEIENCSSRLIVPKAAIFQTQTYLASGKTKTIRHMVANVRGNHIASGSTDTWNGKTLKIPPVTPSILDCCIIRVDYSLAVYIHIPGAKKLMLELPLVIGTIPYNGFGSRNSSIASQFSMDMSWLTLTLPEQPEAPPNYADVVSEEEFSRHIPPYPQPPNCEGEVCCPVFACIQEFRFQPPPLYSEVDPHPSDVEESQPVSFIL
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8NCT1 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T37 | Phosphorylation | Uniprot | |
| Y206 | Phosphorylation | Uniprot | |
| K229 | Ubiquitination | Uniprot | |
| Y291 | Phosphorylation | Uniprot | |
| S292 | Phosphorylation | Uniprot | |
| Y296 | Phosphorylation | Uniprot | |
| Y398 | Phosphorylation | Uniprot |
Research Backgrounds
Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (By similarity). Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) (Probable). Through an ubiquitination-dependent mechanism plays also a role in the incorporation of SLC11A2 into extracellular vesicles (By similarity). May play a role in glucose uptake.
Early endosome. Cell membrane>Peripheral membrane protein>Cytoplasmic side. Cytoplasmic vesicle.
Note: Also found in extracellular vesicles different from exosomes.
Interacts with ADRB2. Interacts (via PPxY motifs) with ITCH, NEDD4L and WWP2. Interacts with AVPR2. Identified in a complex containing at least ARRDC4, AVPR2 and HGS. Interacts with SLC11A2; controls the incorporation of SLC11A2 into extracellular vesicles through an ubiquitination-dependent mechanism (By similarity).
Belongs to the arrestin family.
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