GPRC5C Antibody - #AF9077

(3)  
Product: GPRC5C Antibody
Catalog: AF9077
Description: Rabbit polyclonal antibody to GPRC5C
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Rat, Monkey
Prediction: Bovine, Horse, Sheep, Rabbit, Dog
Mol.Wt.: 48kDa; 48kD(Calculated).
Uniprot: Q9NQ84
RRID: AB_2843268

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat,Monkey
Prediction:
Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%)
Clonality:
Polyclonal
Specificity:
GPRC5C Antibody detects endogenous levels of total GPRC5C.
RRID:
AB_2843268
Cite Format: Affinity Biosciences Cat# AF9077, RRID:AB_2843268.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

G protein coupled receptor family C group 5 member C; G-protein coupled receptor family C group 5 member C; GPC5C_HUMAN; GPCR5C; Gprc5c; MGC131820; Orphan G protein coupled receptor; RAIG-3; RAIG3; Retinoic acid responsive gene protein; Retinoic acid-induced gene 3 protein;

Immunogens

Immunogen:
Uniprot:

Q9NQ84(GPC5C_HUMAN) >>Visit HPA database.

Gene(ID):
GPRC5C(55890)
Expression:
Q9NQ84 GPC5C_HUMAN:

Expression is highest in the periphery, particularly in the stomach, but also in the kidney, liver, pancreas, and prostate. In brain, levels of expression are generally lower than in the periphery, with the exception of cerebellum, spinal cord, and dorsal root ganglia (DRG).

Sequence:
MAIHKALVMCLGLPLFLFPGAWAQGHVPPGCSQGLNPLYYNLCDRSGAWGIVLEAVAGAGIVTTFVLTIILVASLPFVQDTKKRSLLGTQVFFLLGTLGLFCLVFACVVKPDFSTCASRRFLFGVLFAICFSCLAAHVFALNFLARKNHGPRGWVIFTVALLLTLVEVIINTEWLIITLVRGSGEGGPQGNSSAGWAVASPCAIANMDFVMALIYVMLLLLGAFLGAWPALCGRYKRWRKHGVFVLLTTATSVAIWVVWIVMYTYGNKQHNSPTWDDPTLAIALAANAWAFVLFYVIPEVSQVTKSSPEQSYQGDMYPTRGVGYETILKEQKGQSMFVENKAFSMDEPVAAKRPVSPYSGYNGQLLTSVYQPTEMALMHKVPSEGAYDIILPRATANSQVMGSANSTLRAEDMYSAQSHQAATPPKDGKNSQVFRNPYVWD

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Chicken
70
Pig
0
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9NQ84 As Substrate

Site PTM Type Enzyme
S311 Phosphorylation
Y312 Phosphorylation
Y317 Phosphorylation
Y324 Phosphorylation
T326 Phosphorylation
K329 Ubiquitination
K332 Ubiquitination
S335 Phosphorylation
K341 Ubiquitination
S344 Phosphorylation
K352 Ubiquitination
S356 Phosphorylation
Y358 Phosphorylation
S359 Phosphorylation
Y361 Phosphorylation
T367 Phosphorylation
Y370 Phosphorylation
T373 Phosphorylation
S383 Phosphorylation
Y387 Phosphorylation
S398 Phosphorylation
S403 Phosphorylation
S406 Phosphorylation
Y414 Phosphorylation
S415 Phosphorylation
S418 Phosphorylation
T423 Phosphorylation
K429 Ubiquitination
S431 Phosphorylation
Y438 Phosphorylation

Research Backgrounds

Function:

This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.

Subcellular Location:

Cell membrane>Multi-pass membrane protein. Cytoplasmic vesicle membrane>Multi-pass membrane protein.
Note: Localized in the plasma membrane and perinuclear vesicles.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expression is highest in the periphery, particularly in the stomach, but also in the kidney, liver, pancreas, and prostate. In brain, levels of expression are generally lower than in the periphery, with the exception of cerebellum, spinal cord, and dorsal root ganglia (DRG).

Family&Domains:

Belongs to the G-protein coupled receptor 3 family.

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
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