Grap Antibody - #AF9079
| Product: | Grap Antibody |
| Catalog: | AF9079 |
| Description: | Rabbit polyclonal antibody to Grap |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse, Monkey |
| Prediction: | Pig, Bovine |
| Mol.Wt.: | 28kDa; 25kD(Calculated). |
| Uniprot: | Q13588 |
| RRID: | AB_2843270 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF9079, RRID:AB_2843270.
Fold/Unfold
Grap; GRAP_HUMAN; GRB2 related adaptor protein; GRB2-related adapter protein; Growth factor receptor bound protein 2 related adaptor protein; MGC64880; OTTHUMP00000065766;
Immunogens
- Q13588 GRAP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPWYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFLWEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPVHL
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q13588 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K26 | Ubiquitination | Uniprot | |
| K38 | Ubiquitination | Uniprot | |
| K50 | Ubiquitination | Uniprot | |
| K56 | Ubiquitination | Uniprot | |
| K76 | Ubiquitination | Uniprot | |
| S90 | Phosphorylation | Uniprot | |
| Y101 | Phosphorylation | Uniprot | |
| K109 | Ubiquitination | Uniprot | |
| K117 | Ubiquitination | Uniprot | |
| S157 | Phosphorylation | Uniprot | |
| S210 | Phosphorylation | Uniprot |
Research Backgrounds
Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Plays a role in the inner ear and in hearing.
Membrane>Peripheral membrane protein. Cell junction>Synapse.
Note: Localizes at the presynaptic terminal.
Associates through its SH2 domain with ligand-activated receptors for stem cell factor (KIT) and erythropoietin (EPOR). Also forms a stable complex with the Bcr-Abl oncoprotein. GRAP is associated with the Ras guanine nucleotide exchange factor SOS1, primarily through its N-terminal SH3 domain. Interacts with phosphorylated LAT upon TCR activation. Interacts with SHB.
Belongs to the GRB2/sem-5/DRK family.
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