HORMAD1 Antibody - #AF9088
| Product: | HORMAD1 Antibody |
| Catalog: | AF9088 |
| Description: | Rabbit polyclonal antibody to HORMAD1 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 45kDa; 45kD(Calculated). |
| Uniprot: | Q86X24 |
| RRID: | AB_2843279 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF9088, RRID:AB_2843279.
Fold/Unfold
Cancer/testis antigen CT46; CT46; HORMA domain containing 1; HORMA domain containing protein 1; HORMA domain containing protein; Newborn ovary HORMA protein; NOHMA; OTTHUMP00000032933; RP11-363I22 1; Testis tissue sperm binding protein Li 86P;
Immunogens
- Q86X24 HORM1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATAQLQRTPMSALVFPNKISTEHQSLVLVKRLLAVSVSCITYLRGIFPECAYGTRYLDDLCVKILREDKNCPGSTQLVKWMLGCYDALQKKYLRMVVLAVYTNPEDPQTISECYQFKFKYTNNGPLMDFISKNQSNESSMLSTDTKKASILLIRKIYILMQNLGPLPNDVCLTMKLFYYDEVTPPDYQPPGFKDGDCEGVIFEGEPMYLNVGEVSTPFHIFKVKVTTERERMENIDSTILSPKQIKTPFQKILRDKDVEDEQEHYTSDDLDIETKMEEQEKNPASSELEEPSLVCEEDEIMRSKESPDLSISHSQVEQLVNKTSELDMSESKTRSGKVFQNKMANGNQPVKSSKENRKRSQHESGRIVLHHFDSSSQESVPKRRKFSEPKEHI
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q86X24 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S21 | Phosphorylation | Uniprot | |
| S26 | Phosphorylation | Uniprot | |
| S150 | Phosphorylation | Uniprot | |
| S242 | Phosphorylation | Uniprot | |
| S307 | Phosphorylation | Uniprot | |
| S311 | Phosphorylation | Uniprot | |
| S315 | Phosphorylation | Uniprot | |
| S365 | Phosphorylation | Uniprot | |
| S375 | Phosphorylation | Uniprot | |
| S388 | Phosphorylation | Uniprot |
Research Backgrounds
Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes.
Phosphorylated at Ser-377 in a SPO11-dependent manner.
Nucleus. Chromosome.
Note: Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes. The expression of the phosphorylated form at Ser-377 is restricted to unsynapsed chromosomal regions (By similarity).
Testis-specific. Over-expressed in carcinomas.
Interacts with HORMAD2. Interacts with IHO1/CCDC36.
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