LONP2 Antibody - #AF9105
| Product: | LONP2 Antibody |
| Catalog: | AF9105 |
| Description: | Rabbit polyclonal antibody to LONP2 |
| Application: | WB |
| Reactivity: | Human |
| Prediction: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 95kDa; 95kD(Calculated). |
| Uniprot: | Q86WA8 |
| RRID: | AB_2843295 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF9105, RRID:AB_2843295.
Fold/Unfold
Lon peptidase 2, peroxisomal; Lon protease 2; Lon protease homolog 2; Lon protease homolog 2 peroxisomal; Lon protease like protein 2; Lon protease-like protein 2; LONP; lonp2; LONP2_HUMAN; LONPL; MGC4840; peroxisomal; Peroxisomal Lon protease; Peroxisomal Lon protease homolog 2; Peroxisomal LON protease like;
Immunogens
- Q86WA8 LONP2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSSVSPIQIPSRLPLLLTHEGVLLPGSTMRTSVDSARNLQLVRSRLLKGTSLQSTILGVIPNTPDPASDAQDLPPLHRIGTAALAVQVVGSNWPKPHYTLLITGLCRFQIVQVLKEKPYPIAEVEQLDRLEEFPNTCKMREELGELSEQFYKYAVQLVEMLDMSVPAVAKLRRLLDSLPREALPDILTSIIRTSNKEKLQILDAVSLEERFKMTIPLLVRQIEGLKLLQKTRKPKQDDDKRVIAIRPIRRITHISGTLEDEDEDEDNDDIVMLEKKIRTSSMPEQAHKVCVKEIKRLKKMPQSMPEYALTRNYLELMVELPWNKSTTDRLDIRAARILLDNDHYAMEKLKKRVLEYLAVRQLKNNLKGPILCFVGPPGVGKTSVGRSVAKTLGREFHRIALGGVCDQSDIRGHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKSLQGDPAAALLEVLDPEQNHNFTDHYLNVAFDLSQVLFIATANTTATIPAALLDRMEIIQVPGYTQEEKIEIAHRHLIPKQLEQHGLTPQQIQIPQVTTLDIITRYTREAGVRSLDRKLGAICRAVAVKVAEGQHKEAKLDRSDVTEREGCREHILEDEKPESISDTTDLALPPEMPILIDFHALKDILGPPMYEMEVSQRLSQPGVAIGLAWTPLGGEIMFVEASRMDGEGQLTLTGQLGDVMKESAHLAISWLRSNAKKYQLTNAFGSFDLLDNTDIHLHFPAGAVTKDGPSAGVTIVTCLASLFSGRLVRSDVAMTGEITLRGLVLPVGGIKDKVLAAHRAGLKQVIIPRRNEKDLEGIPGNVRQDLSFVTASCLDEVLNAAFDGGFTVKTRPGLLNSKL
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q86WA8 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| S68 | Phosphorylation | Uniprot | |
| K117 | Ubiquitination | Uniprot | |
| Y307 | Phosphorylation | Uniprot | |
| Y344 | Phosphorylation | Uniprot | |
| K348 | Ubiquitination | Uniprot | |
| Y356 | Phosphorylation | Uniprot | |
| K367 | Ubiquitination | Uniprot | |
| S387 | Phosphorylation | Uniprot | |
| T416 | Phosphorylation | Uniprot | |
| K446 | Ubiquitination | Uniprot | |
| K567 | Ubiquitination | Uniprot | |
| S592 | Phosphorylation | Uniprot | |
| K709 | Acetylation | Uniprot | |
| Y711 | Phosphorylation | Uniprot |
Research Backgrounds
ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.
Peroxisome matrix.
Widely expressed, with high levels in the liver, kidney and pancreas.
Interacts with PEX5 (By similarity). Interacts with TYSND1 (By similarity). May interact with enzymes involved in beta-oxidation of fatty acids, including ACOX1/AOX.
Belongs to the peptidase S16 family.
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