PSK-H1 Antibody - #AF9170
| Product: | PSK-H1 Antibody |
| Catalog: | AF9170 |
| Description: | Rabbit polyclonal antibody to PSK-H1 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Rat |
| Prediction: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
| Mol.Wt.: | 48kDa; 48kD(Calculated). |
| Uniprot: | P11801 |
| RRID: | AB_2843360 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF9170, RRID:AB_2843360.
Fold/Unfold
KPSH1_HUMAN; Protein serine kinase H1; PSK H1; PSK-H1; PSKH1; Serine/threonine protein kinase H1; Serine/threonine-protein kinase H1;
Immunogens
Expressed in all tissues and cell lines tested with the highest level of abundance in testis.
- P11801 KPSH1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGCGTSKVLPEPPKDVQLDLVKKVEPFSGTKSDVYKHFITEVDSVGPVKAGFPAASQYAHPCPGPPTAGHTEPPSEPPRRARVAKYRAKFDPRVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGREVCESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRASSRCQSTKSAQSTRSSRSTRSNKSRRVRERELRELNLRYQQQYNG
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P11801 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| G2 | Myristoylation | Uniprot | |
| Y35 | Phosphorylation | Uniprot | |
| T164 | Phosphorylation | Uniprot | |
| T176 | Phosphorylation | Uniprot | |
| K187 | Ubiquitination | Uniprot |
Research Backgrounds
May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing.
Autophosphorylated on serine residues.
Myristoylated. Required for membrane association. Prerequisite for palmitoylation to occur.
Palmitoylated.
Golgi apparatus. Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome. Nucleus speckle. Endoplasmic reticulum membrane>Lipid-anchor. Cell membrane>Lipid-anchor. Cytoplasm.
Note: Localized in the brefeldin A-sensitive Golgi compartment, at centrosomes, in the nucleus with a somewhat speckle-like presence, membrane-associated to the endoplasmic reticulum (ER) and the plasma membrane (PM), and more diffusely in the cytoplasm. Found to concentrate in splicing factor compartments (SFCs) within the nucleus of interphase cells. The acylation-negative form may be only cytoplasmic and nuclear. Acylation seems to allow the sequestering to the intracellular membranes. Myristoylation may mediate targeting to the intracellular non-Golgi membranes and palmitoylation may mediate the targeting to the Golgi membranes. Dual acylation is required to stabilize the interaction with Golgi membranes.
Expressed in all tissues and cell lines tested with the highest level of abundance in testis.
Homodimer.
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
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