STOML2 Antibody - #DF12010
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12010, RRID:AB_2844815.
Fold/Unfold
EPB72 like protein 2; EPB72-like protein 2; HSPC108; OTTHUMP00000021320; Paraprotein target 7; Paratarg 7; SLP 2; SLP-2; SLP2; STML2_HUMAN; Stomatin (EPB72) like 2; Stomatin like 2; Stomatin like protein 2; Stomatin like protein 2, mitochondrial; Stomatin-like protein 2; STOML2;
Immunogens
Ubiquitously expressed at low levels. Expressed in lymphoid tissues (at protein level).
- Q9UJZ1 STML2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLARAARGTGALLLRGSLLASGRAPRRASSGLPRNTVVLFVPQQEAWVVERMGRFHRILEPGLNILIPVLDRIRYVQSLKEIVINVPEQSAVTLDNVTLQIDGVLYLRIMDPYKASYGVEDPEYAVTQLAQTTMRSELGKLSLDKVFRERESLNASIVDAINQAADCWGIRCLRYEIKDIHVPPRVKESMQMQVEAERRKRATVLESEGTRESAINVAEGKKQAQILASEAEKAEQINQAAGEASAVLAKAKAKAEAIRILAAALTQHNGDAAASLTVAEQYVSAFSKLAKDSNTILLPSNPGDVTSMVAQAMGVYGALTKAPVPGTPDSLSSGSSRDVQGTDASLDEELDRVKMS
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9UJZ1 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S17 | Phosphorylation | Uniprot | |
| S29 | Phosphorylation | Uniprot | |
| R74 | Methylation | Uniprot | |
| K114 | Acetylation | Uniprot | |
| K114 | Ubiquitination | Uniprot | |
| Y124 | Phosphorylation | Uniprot | |
| K140 | Ubiquitination | Uniprot | |
| S142 | Phosphorylation | Uniprot | |
| K145 | Acetylation | Uniprot | |
| K145 | Ubiquitination | Uniprot | |
| S207 | Phosphorylation | Uniprot | |
| K221 | Acetylation | Uniprot | |
| K222 | Acetylation | Uniprot | |
| S229 | Phosphorylation | Uniprot | |
| K233 | Acetylation | Uniprot | |
| K250 | Ubiquitination | Uniprot | |
| S300 | Phosphorylation | Uniprot | |
| T306 | Phosphorylation | Uniprot | |
| S307 | Phosphorylation | Uniprot | |
| T327 | Phosphorylation | Uniprot | |
| S330 | Phosphorylation | Uniprot | |
| S332 | Phosphorylation | Uniprot | |
| S333 | Phosphorylation | Uniprot | |
| S335 | Phosphorylation | Uniprot | |
| T342 | Phosphorylation | Uniprot | |
| S345 | Phosphorylation | Uniprot |
Research Backgrounds
Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation.
Hyperphosphorylated at Ser-17 in some patients with monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma (MM) and Waldenstrom macroglobulinemia due to impaired dephosphorylation by PP2A.
Cell membrane>Peripheral membrane protein. Mitochondrion. Mitochondrion inner membrane>Lipid-anchor. Mitochondrion intermembrane space. Membrane raft. Cytoplasm>Cytoskeleton.
Note: Behaves as an integral membrane protein of the mitochondrion despite the absence of a detectable transmembrane domain (PubMed:21746876). Also associates with the actin cytoskeleton and membrane rafts in activated T-cells (PubMed:18641330, PubMed:10713127). A minor pool is associated with the plasma membrane and is enriched at the immunological synapse in activated T-cells (PubMed:22623988).
Ubiquitously expressed at low levels. Expressed in lymphoid tissues (at protein level).
Forms homooligomers. Interacts with MFN2; may form heterooligomers. Interacts with CACNA2D2 (By similarity). Interacts with PHB and PHB2; recruits them to cardiolipin-enriched mitochondrial membranes and stabilizes them.
Belongs to the band 7/mec-2 family.
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