CAPRIN1 Antibody - #DF12012

(2)  
Product: CAPRIN1 Antibody
Catalog: DF12012
Description: Rabbit polyclonal antibody to CAPRIN1
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Sheep, Dog, Chicken
Mol.Wt.: 100-120kD; 78kD(Calculated).
Uniprot: Q14444
RRID: AB_2844817

View similar products>>

   Size Price Inventory
 100ul $280 In stock
 200ul $350 In stock

Lead Time: Same day delivery

For pricing and ordering contact:
Local distributors
Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Bovine(100%), Horse(88%), Sheep(100%), Dog(100%), Chicken(88%)
Clonality:
Polyclonal
Specificity:
CAPRIN1 Antibody detects endogenous levels of total CAPRIN1.
RRID:
AB_2844817
Cite Format: Affinity Biosciences Cat# DF12012, RRID:AB_2844817.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

activation/proliferation-associated protein 1; CAPR1_HUMAN; Caprin-1; CAPRIN1; Cell cycle-associated protein 1; Cytoplasmic activation- and proliferation-associated protein 1; cytoplasmic activation/proliferation-associated protein-1; GPI-anchored membrane protein 1; GPI-anchored protein p137; GPI-p137; GPIAP1; M11S1; Membrane component chromosome 11 surface marker 1; p137GPI; RNA granule protein 105; RNG105;

Immunogens

Immunogen:
Uniprot:

Q14444(CAPR1_HUMAN) >>Visit HPA database.

Gene(ID):
CAPRIN1(4076)
Expression:
Q14444 CAPR1_HUMAN:

Ubiquitous.

Sequence:
MPSATSHSGSGSKSSGPPPPSGSSGSEAAAGAGAAAPASQHPATGTGAVQTEAMKQILGVIDKKLRNLEKKKGKLDDYQERMNKGERLNQDQLDAVSKYQEVTNNLEFAKELQRSFMALSQDIQKTIKKTARREQLMREEAEQKRLKTVLELQYVLDKLGDDEVRTDLKQGLNGVPILSEEELSLLDEFYKLVDPERDMSLRLNEQYEHASIHLWDLLEGKEKPVCGTTYKVLKEIVERVFQSNYFDSTHNHQNGLCEEEEAASAPAVEDQVPEAEPEPAEEYTEQSEVESTEYVNRQFMAETQFTSGEKEQVDEWTVETVEVVNSLQQQPQAASPSVPEPHSLTPVAQADPLVRRQRVQDLMAQMQGPYNFIQDSMLDFENQTLDPAIVSAQPMNPTQNMDMPQLVCPPVHSESRLAQPNQVPVQPEATQVPLVSSTSEGYTASQPLYQPSHATEQRPQKEPIDQIQATISLNTDQTTASSSLPAASQPQVFQAGTSKPLHSSGINVNAAPFQSMQTVFNMNAPVPPVNEPETLKQQNQYQASYNQSFSSQPHQVEQTELQQEQLQTVVGTYHGSPDQSHQVTGNHQQPPQQNTGFPRSNQPYYNSRGVSRGGSRGARGLMNGYRGPANGFRGGYDGYRPSFSNTPNSGYTQSQFSAPRDYSGYQRDGYQQNFKRGSGQSGPRGAPRGRGGPPRPNRGMPQMNTQQVN

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Bovine
100
Sheep
100
Dog
100
Horse
88
Chicken
88
Xenopus
0
Zebrafish
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q14444 As Substrate

Site PTM Type Enzyme
P2 Acetylation
S6 Phosphorylation
S8 Phosphorylation
S10 Phosphorylation
S12 Phosphorylation
S23 Phosphorylation
S39 Phosphorylation
K55 Ubiquitination
K63 Ubiquitination
K64 Ubiquitination
K74 Acetylation
K74 Methylation
K74 Ubiquitination
Y78 Phosphorylation
R81 Methylation
S97 Phosphorylation
K98 Ubiquitination
K110 Methylation
K110 Ubiquitination
S115 Phosphorylation
K125 Ubiquitination
T126 Phosphorylation
K128 Ubiquitination
K129 Ubiquitination
K147 Ubiquitination
Y154 Phosphorylation
K158 Ubiquitination
K169 Ubiquitination
S179 Phosphorylation
S200 Phosphorylation
K221 Ubiquitination
K223 Ubiquitination
C226 S-Nitrosylation
K231 Acetylation
K231 Ubiquitination
K234 Ubiquitination
S264 Phosphorylation
Y283 Phosphorylation
S287 Phosphorylation
T292 Phosphorylation
Y294 Phosphorylation
S307 Phosphorylation
S335 Phosphorylation
S337 Phosphorylation
S343 Phosphorylation
T345 Phosphorylation
T398 Phosphorylation
Y442 Phosphorylation
Y449 Phosphorylation
Y541 Phosphorylation
Y545 Phosphorylation
T572 Phosphorylation
Y573 Phosphorylation
R608 Methylation
S611 Phosphorylation
R612 Methylation
S615 Phosphorylation
R616 Methylation
R619 Methylation
R626 Methylation
R633 Methylation
Y636 Phosphorylation
R640 Methylation
S642 Phosphorylation
T646 Phosphorylation
Y651 Phosphorylation
T652 Phosphorylation
S657 Phosphorylation
Y662 Phosphorylation
Y665 Phosphorylation
R667 Methylation
Y670 Phosphorylation
K675 Methylation
S681 Phosphorylation
R690 Methylation
R695 Methylation
R698 Methylation

Research Backgrounds

Function:

May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs.

PTMs:

O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.

Subcellular Location:

Cytoplasm>Cytosol. Cell projection>Dendrite.
Note: Associated with RNA granules.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Ubiquitous.

Subunit Structure:

May form homomultimers (By similarity). Interacts with G3BP1; interaction is direct and takes place in cytoplasmic RNA granules. Interacts with PQBP1.

Family&Domains:

Belongs to the caprin family.

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.