YME1L1 Antibody - #DF12024
| Product: | YME1L1 Antibody |
| Catalog: | DF12024 |
| Description: | Rabbit polyclonal antibody to YME1L1 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Sheep, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 86 kDa; 86kD(Calculated). |
| Uniprot: | Q96TA2 |
| RRID: | AB_2844829 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12024, RRID:AB_2844829.
Fold/Unfold
ATP dependent metalloprotease FtsH1 homolog; ATP-dependent metalloprotease FtsH1; ATP-dependent zinc metalloprotease YME1L1; FTSH1; Meg-4; MEG4; PAMP; Presenilin-associated metalloprotease; UNQ1868/PRO4304; YME1 like 1; YME1-like protein 1; YME1L; Yme1l1; YMEL1_HUMAN;
Immunogens
- Q96TA2 YMEL1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MFSLSSTVQPQVTVPLSHLINAFHTPKNTSVSLSGVSVSQNQHRDVVPEHEAPSSECMFSDFLTKLNIVSIGKGKIFEGYRSMFMEPAKRMKKSLDTTDNWHIRPEPFSLSIPPSLNLRDLGLSELKIGQIDQLVENLLPGFCKGKNISSHWHTSHVSAQSFFENKYGNLDIFSTLRSSCLYRHHSRALQSICSDLQYWPVFIQSRGFKTLKSRTRRLQSTSERLAETQNIAPSFVKGFLLRDRGSDVESLDKLMKTKNIPEAHQDAFKTGFAEGFLKAQALTQKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFRTTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTILGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTYSDTGKLSPETQSAIEQEIRILLRDSYERAKHILKTHAKEHKNLAEALLTYETLDAKEIQIVLEGKKLEVR
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q96TA2 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S220 | Phosphorylation | Uniprot | |
| T221 | Phosphorylation | Uniprot | |
| K237 | Acetylation | Uniprot | |
| K237 | Ubiquitination | Uniprot | |
| K253 | Ubiquitination | Uniprot | |
| K258 | Ubiquitination | Uniprot | |
| K269 | Ubiquitination | Uniprot | |
| T270 | Phosphorylation | Uniprot | |
| K278 | Ubiquitination | Uniprot | |
| Y306 | Phosphorylation | Uniprot | |
| S315 | Phosphorylation | Uniprot | |
| K334 | Ubiquitination | Uniprot | |
| K342 | Ubiquitination | Uniprot | |
| K348 | Ubiquitination | Uniprot | |
| K359 | Ubiquitination | Uniprot | |
| K363 | Ubiquitination | Uniprot | |
| K370 | Ubiquitination | Uniprot | |
| K385 | Ubiquitination | Uniprot | |
| K446 | Ubiquitination | Uniprot | |
| K522 | Ubiquitination | Uniprot | |
| K524 | Ubiquitination | Uniprot | |
| K556 | Ubiquitination | Uniprot | |
| K562 | Ubiquitination | Uniprot | |
| K568 | Ubiquitination | Uniprot | |
| K691 | Ubiquitination | Uniprot | |
| S704 | Phosphorylation | Uniprot | |
| K708 | Ubiquitination | Uniprot | |
| S710 | Phosphorylation | Uniprot | |
| K737 | Ubiquitination | Uniprot | |
| K744 | Ubiquitination | Uniprot | |
| K768 | Ubiquitination | Uniprot |
Research Backgrounds
ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region. Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Required for normal, constitutive degradation of PRELID1. Catalyzes the degradation of OMA1 in response to membrane depolarization. Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1).
Proteolytically processed by mitochondrial processing peptidase (MPP) to generate the mature form.
Mitochondrion inner membrane. Mitochondrion.
High expression in cardiac and skeletal muscle mitochondria.
Homohexamer; may also form heterohexamers. Exists in several complexes of 600-1100 kDa. Interacts with AFG1L.
In the N-terminal section; belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
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