LMOD3 Antibody - #DF12057
| Product: | LMOD3 Antibody |
| Catalog: | DF12057 |
| Description: | Rabbit polyclonal antibody to LMOD3 |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Mol.Wt.: | 65-70 kDa; 65kD(Calculated). |
| Uniprot: | Q0VAK6 |
| RRID: | AB_2844862 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12057, RRID:AB_2844862.
Fold/Unfold
fetal form; Leiomodin; Leiomodin-3; LMOD3; LMOD3_HUMAN;
Immunogens
Expressed in cardiac and at higher levels in skeletal muscles (at protein level).
- Q0VAK6 LMOD3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSEHSRNSDQEELLDEEINEDEILANLSAEELKELQSEMEVMAPDPSLPVGMIQKDQTDKPPTGNFNHKSLVDYMYWEKASRRMLEEERVPVTFVKSEEKTQEEHEEIEKRNKNMAQYLKEKLNNEIVANKRESKGSSNIQETDEEDEEEEDDDDDDEGEDDGEESEETNREEEGKAKEQIRNCENNCQQVTDKAFKEQRDRPEAQEQSEKKISKLDPKKLALDTSFLKVSTRPSGNQTDLDGSLRRVRKNDPDMKELNLNNIENIPKEMLLDFVNAMKKNKHIKTFSLANVGADENVAFALANMLRENRSITTLNIESNFITGKGIVAIMRCLQFNETLTELRFHNQRHMLGHHAEMEIARLLKANNTLLKMGYHFELPGPRMVVTNLLTRNQDKQRQKRQEEQKQQQLKEQKKLIAMLENGLGLPPGMWELLGGPKPDSRMQEFFQPPPPRPPNPQNVPFSQRSEMMKKPSQAPKYRTDPDSFRVVKLKRIQRKSRMPEAREPPEKTNLKDVIKTLKPVPRNRPPPLVEITPRDQLLNDIRHSSVAYLKPVQLPKELA
PTMs - Q0VAK6 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S8 | Phosphorylation | Uniprot | |
| Y375 | Phosphorylation | Uniprot | |
| T517 | Phosphorylation | Uniprot |
Research Backgrounds
Essential for the organization of sarcomeric actin thin filaments in skeletal muscle. Increases the rate of actin polymerization.
Ubiquitinated, leading to its degradation. Interaction with KLHL40 negatively regulates ubiquitination and degradation.
Cytoplasm. Cytoplasm>Myofibril>Sarcomere>M line. Cytoplasm>Myofibril>Sarcomere>A band. Cytoplasm>Cytoskeleton.
Note: Highly expressed in nonstriated areas of developing myotubes, where it shows a granular cytoplasmic pattern. In sarcomeres, highly expressed in the M band region and, at lower levels, along actin thin filaments. Not detected in Z-disks. In sarcomeres, may be located near, but not at, actin thin filament pointed end.
Expressed in cardiac and at higher levels in skeletal muscles (at protein level).
May interact with tropomyosin alpha (TPM1/2) N-terminus. Interacts with KLHL40; leading to stabilization (By similarity).
Belongs to the tropomodulin family.
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