Liprin alpha 1 Antibody - #DF12102

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Product: Liprin alpha 1 Antibody
Catalog: DF12102
Description: Rabbit polyclonal antibody to Liprin alpha 1
Application: WB IHC
Reactivity: Human, Mouse, Rat
Prediction: Rabbit, Dog, Chicken, Xenopus
Mol.Wt.: 160 kDa; 136kD(Calculated).
Uniprot: Q13136
RRID: AB_2844907

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Rabbit(92%), Dog(92%), Chicken(92%), Xenopus(92%)
Clonality:
Polyclonal
Specificity:
Liprin alpha 1 Antibody detects endogenous levels of total Liprin alpha 1.
RRID:
AB_2844907
Cite Format: Affinity Biosciences Cat# DF12102, RRID:AB_2844907.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

FLJ42630; HGNC:9245; LAR interacting protein 1; LAR-interacting protein 1; LIP 1; LIP-1; LIP.1; LIP1; LIPA1_HUMAN; LIPRIN; Liprin-alpha-1; MGC26800; PPFIA 1; PPFIA1; Protein tyrosine phosphatase receptor type f polypeptide (PTPRF) interacting protein (liprin) alpha 1; Protein tyrosine phosphatase receptor type f polypeptide interacting protein alpha 1; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1; PTPRF interacting protein alpha 1; PTPRF-interacting protein alpha-1;

Immunogens

Immunogen:
Uniprot:

Q13136(LIPA1_HUMAN) >>Visit HPA database.

Gene(ID):
PPFIA1(8500)
Expression:
Q13136 LIPA1_HUMAN:

Ubiquitous.

Sequence:
MMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSGSLDNLGRFRSMSSIPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDRLGVMTLLPPSREEVRDDKTTIKCETSPPSSPRALRLDRLHKGALHTVSHEDIRDIRNSTGSQDGPVSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQAGVSETDNSSQDALGLSKLGGQAEKNRKLQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEIMSLTSPSAPPTSRTTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCGIMCLRRLNYDRKELERKREESQSEIKDVLVWSNDRVIRWILSIGLKEYANNLIESGVHGALLALDETFDFSALALLLQIPTQNTQARAVLEREFNNLLVMGTDRRFDEDDDKSFRRAPSWRKKFRPKDIRGLAAGSAETLPANFRVTSSMSSPSMQPKKMQMDGNVSGTQRLDSATVRTYSC

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Dog
92
Xenopus
92
Chicken
92
Rabbit
92
Pig
67
Bovine
67
Sheep
67
Horse
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q13136 As Substrate

Site PTM Type Enzyme
S77 Phosphorylation
K95 Ubiquitination
S138 Phosphorylation
S150 Phosphorylation
T230 Phosphorylation
S234 Phosphorylation
S238 Phosphorylation
S239 Phosphorylation
S242 Phosphorylation
S244 Phosphorylation
S275 Phosphorylation
S297 Phosphorylation
T302 Phosphorylation
K404 Ubiquitination
S448 Phosphorylation
S458 Phosphorylation
K467 Ubiquitination
K476 Acetylation
S485 Phosphorylation
S520 Phosphorylation
S530 Phosphorylation
R535 Methylation
S545 Phosphorylation
Y546 Phosphorylation
S547 Phosphorylation
T548 Phosphorylation
S549 Phosphorylation
S568 Phosphorylation
K569 Ubiquitination
T572 Phosphorylation
S601 Phosphorylation
S666 Phosphorylation
S668 Phosphorylation
Y684 Phosphorylation
S687 Phosphorylation
S688 Phosphorylation
S691 Phosphorylation
S692 Phosphorylation
S693 Phosphorylation
S697 Phosphorylation
S700 Phosphorylation
T701 Phosphorylation
S708 Phosphorylation
T734 Phosphorylation
T735 Phosphorylation
T740 Phosphorylation
S741 Phosphorylation
S744 Phosphorylation
S745 Phosphorylation
K756 Ubiquitination
T761 Phosphorylation
S763 Phosphorylation
S773 Phosphorylation
T774 Phosphorylation
S776 Phosphorylation
S785 Phosphorylation
S787 Phosphorylation
S790 Phosphorylation
S793 Phosphorylation
K801 Acetylation
K804 Acetylation
S805 Phosphorylation
S806 Phosphorylation
K847 Ubiquitination
S915 Phosphorylation
S946 Phosphorylation
S1133 Phosphorylation
S1139 Phosphorylation
S1156 Phosphorylation
T1159 Phosphorylation
S1171 Phosphorylation
S1172 Phosphorylation
S1174 Phosphorylation

Research Backgrounds

Function:

May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.

Subcellular Location:

Cytoplasm.
Note: Colocalizes with PTPRF at the ends of focal adhesions most proximal to the cell nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Ubiquitous.

Subunit Structure:

Forms homodimers and heterodimers with liprins-alpha and liprins-beta. Interacts with the second PTPase domain of PTPRD, PTPRF and PTPRS. Interacts with GIT1, KIF1A and GRIP1 (By similarity).

Family&Domains:

The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS.

Belongs to the liprin family. Liprin-alpha subfamily.

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