PBXIP1 Antibody - #DF12129
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12129, RRID:AB_2844934.
Fold/Unfold
4732463H20Rik; Hematopoietic PBX interacting protein; HPIP; MGC38361; Pre B cell leukemia homeobox interacting protein 1; RP11-307C12.2;
Immunogens
- Q96AQ6 PBIP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASCPDSDNSWVLAGSESLPVETLGPASRMDPESERALQAPHSPSKTDGKELAGTMDGEGTLFQTESPQSGSILTEETEVKGTLEGDVCGVEPPGPGDTVVQGDLQETTVVTGLGPDTQDLEGQSPPQSLPSTPKAAWIREEGRCSSSDDDTDVDMEGLRRRRGREAGPPQPMVPLAVENQAGGEGAGGELGISLNMCLLGALVLLGLGVLLFSGGLSESETGPMEEVERQVLPDPEVLEAVGDRQDGLREQLQAPVPPDSVPSLQNMGLLLDKLAKENQDIRLLQAQLQAQKEELQSLMHQPKGLEEENAQLRGALQQGEAFQRALESELQQLRARLQGLEADCVRGPDGVCLSGGRGPQGDKAIREQGPREQEPELSFLKQKEQLEAEAQALRQELERQRRLLGSVQQDLERSLQDASRGDPAHAGLAELGHRLAQKLQGLENWGQDPGVSANASKAWHQKSHFQNSREWSGKEKWWDGQRDRKAEHWKHKKEESGRERKKNWGGQEDREPAGRWKEGRPRVEESGSKKEGKRQGPKEPPRKSGSFHSSGEKQKQPRWREGTKDSHDPLPSWAELLRPKYRAPQGCSGVDECARQEGLTFFGTELAPVRQQELASLLRTYLARLPWAGQLTKELPLSPAFFGEDGIFRHDRLRFRDFVDALEDSLEEVAVQQTGDDDEVDDFEDFIFSHFFGDKALKKRSGKKDKHSQSPRAAGPREGHSHSHHHHHRG
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q96AQ6 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S7 | Phosphorylation | Uniprot | |
| S16 | Phosphorylation | Uniprot | |
| T23 | Phosphorylation | Uniprot | |
| S43 | Phosphorylation | Uniprot | |
| S45 | Phosphorylation | Uniprot | |
| T47 | Phosphorylation | Uniprot | |
| S67 | Phosphorylation | Uniprot | |
| S125 | Phosphorylation | Uniprot | |
| S129 | Phosphorylation | Uniprot | |
| S132 | Phosphorylation | Uniprot | |
| T133 | Phosphorylation | Uniprot | |
| S146 | Phosphorylation | Uniprot | |
| S147 | Phosphorylation | Uniprot | |
| S148 | Phosphorylation | Uniprot | |
| T152 | Phosphorylation | Uniprot | |
| K274 | Ubiquitination | Uniprot | |
| K277 | Ubiquitination | Uniprot | |
| K293 | Ubiquitination | Uniprot | |
| K304 | Ubiquitination | Uniprot | |
| K382 | Ubiquitination | Uniprot | |
| K384 | Ubiquitination | Uniprot | |
| S407 | Phosphorylation | Uniprot | |
| K463 | Ubiquitination | Uniprot | |
| S469 | Phosphorylation | Uniprot | |
| K531 | Methylation | Uniprot | |
| K534 | Acetylation | Uniprot | |
| K539 | Acetylation | Uniprot | |
| K539 | Methylation | Uniprot | |
| S617 | Phosphorylation | Uniprot | |
| K634 | Ubiquitination | Uniprot | |
| S639 | Phosphorylation | Uniprot |
Research Backgrounds
Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.
Cytoplasm>Cytoskeleton. Nucleus.
Note: Shuttles between the nucleus and the cytosol (PubMed:12360403). Mainly localized in the cytoplasm, associated with microtubules (PubMed:10825160, PubMed:12360403). Detected in small amounts in the nucleus (PubMed:10825160).
Expressed in early hematopoietic precursors.
Interacts with TEX11 (By similarity). Interacts with ESR1, PBX1, PBX2 and PBX3.
The C-terminal domain (AA 443-731) contains a nuclear export signal.
Association to the cytoskeleton through a N-terminal leucine rich-domain (AA 190-218).
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