PTPN23 Antibody - #DF12169

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Product: PTPN23 Antibody
Catalog: DF12169
Description: Rabbit polyclonal antibody to PTPN23
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Rabbit, Dog
Mol.Wt.: 179 kDa; 179kD(Calculated).
Uniprot: Q9H3S7
RRID: AB_2844974

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Bovine(100%), Horse(100%), Rabbit(100%), Dog(100%)
Clonality:
Polyclonal
Specificity:
PTPN23 Antibody detects endogenous levels of total PTPN23.
RRID:
AB_2844974
Cite Format: Affinity Biosciences Cat# DF12169, RRID:AB_2844974.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

DKFZP564F0923; EC 3.1.3.48; HD PTP; HD-PTP; His domain containing protein tyrosine phosphatase; His domain protein tyrosine phosphatase; His domain-containing protein tyrosine phosphatase; KIAA1471; Protein tyrosine phosphatase non receptor type 23; Protein tyrosine phosphatase TD 14; Protein tyrosine phosphatase TD14; PTN23_HUMAN; PTP TD14; PTP-TD14; PTPN 23; PTPN23; Tyrosine protein phosphatase non receptor type 23; Tyrosine-protein phosphatase non-receptor type 23;

Immunogens

Immunogen:
Uniprot:

Q9H3S7(PTN23_HUMAN) >>Visit HPA database.

Gene(ID):
PTPN23(25930)
Sequence:
MEAVPRMPMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEELKKLELLRQNAVRVPRDFEGCSVLRKYLGQLHYLQSRVPMGSGQEAAVPVTWTEIFSGKSVAHEDIKYEQACILYNLGALHSMLGAMDKRVSEEGMKVSCTHFQCAAGAFAYLREHFPQAYSVDMSRQILTLNVNLMLGQAQECLLEKSMLDNRKSFLVARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKLVQMKIYYFAAVAHLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDTVQDALRFTMDVIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPAVTGPDIFAKLVPMAAHEASSLYSEEKAKLLREMMAKIEDKNEVLDQFMDSMQLDPETVDNLDAYSHIPPQLMEKCAALSVRPDTVRNLVQSMQVLSGVFTDVEASLKDIRDLLEEDELLEQKFQEAVGQAGAISITSKAELAEVRREWAKYMEVHEKASFTNSELHRAMNLHVGNLRLLSGPLDQVRAALPTPALSPEDKAVLQNLKRILAKVQEMRDQRVSLEQQLRELIQKDDITASLVTTDHSEMKKLFEEQLKKYDQLKVYLEQNLAAQDRVLCALTEANVQYAAVRRVLSDLDQKWNSTLQTLVASYEAYEDLMKKSQEGRDFYADLESKVAALLERTQSTCQAREAARQQLLDRELKKKPPPRPTAPKPLLPRREESEAVEAGDPPEELRSLPPDMVAGPRLPDTFLGSATPLHFPPSPFPSSTGPGPHYLSGPLPPGTYSGPTQLIQPRAPGPHAMPVAPGPALYPAPAYTPELGLVPRSSPQHGVVSSPYVGVGPAPPVAGLPSAPPPQFSGPELAMAVRPATTTVDSIQAPIPSHTAPRPNPTPAPPPPCFPVPPPQPLPTPYTYPAGAKQPIPAQHHFSSGIPAGFPAPRIGPQPQPHPQPHPSQAFGPQPPQQPLPLQHPHLFPPQAPGLLPPQSPYPYAPQPGVLGQPPPPLHTQLYPGPAQDPLPAHSGALPFPSPGPPQPPHPPLAYGPAPSTRPMGPQAAPLTIRGPSSAGQSTPSPHLVPSPAPSPGPGPVPPRPPAAEPPPCLRRGAAAADLLSSSPESQHGGTQSPGGGQPLLQPTKVDAAEGRRPQALRLIERDPYEHPERLRQLQQELEAFRGQLGDVGALDTVWRELQDAQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQVLQRHGVPPPCKPLASASISQKNHLPQDSQDLVLGGDVPISSIQATIAKLSIRPPGGLESPVASLPGPAEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKEEPPVPEAPSSGPPSSSLELLASLTPEAFSLDSSLRGKQRMSKHNFLQAHNGQGLRATRPSDDPLSLLDPLWTLNKT

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Dog
100
Rabbit
100
Sheep
0
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9H3S7 As Substrate

Site PTM Type Enzyme
K28 Ubiquitination
K32 Ubiquitination
K46 Ubiquitination
S66 Phosphorylation
K70 Ubiquitination
Y213 Phosphorylation
K215 Ubiquitination
K279 Ubiquitination
K285 Ubiquitination
K288 Ubiquitination
T293 Phosphorylation
K314 Ubiquitination
K340 Ubiquitination
K359 Ubiquitination
S370 Phosphorylation
K472 Ubiquitination
S484 Phosphorylation
K500 Ubiquitination
S509 Phosphorylation
T511 Phosphorylation
S513 Phosphorylation
K550 Ubiquitination
K557 Ubiquitination
T587 Phosphorylation
S589 Phosphorylation
K600 Ubiquitination
K608 Methylation
K613 Methylation
S645 Phosphorylation
Y679 Phosphorylation
T693 Phosphorylation
T696 Phosphorylation
R730 Methylation
S733 Phosphorylation
S747 Phosphorylation
R950 Methylation
S1121 Phosphorylation
S1122 Phosphorylation
S1123 Phosphorylation
S1126 Phosphorylation
T1131 Phosphorylation
S1133 Phosphorylation
Y1165 Phosphorylation
S1210 Phosphorylation
S1218 Phosphorylation
K1220 Ubiquitination
Y1229 Phosphorylation
S1290 Phosphorylation
S1335 Phosphorylation
C1466 S-Nitrosylation
S1475 Phosphorylation
S1484 Phosphorylation
S1542 Phosphorylation
S1549 Phosphorylation
S1589 Phosphorylation
S1593 Phosphorylation
R1595 Methylation
S1601 Phosphorylation
R1615 Methylation
R1618 Methylation
S1620 Phosphorylation
S1625 Phosphorylation
T1632 Phosphorylation
K1635 Ubiquitination
T1636 Phosphorylation

Research Backgrounds

Function:

Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis.

Subcellular Location:

Nucleus. Cytoplasm. Cytoplasmic vesicle. Endosome. Cytoplasm>Cytoskeleton>Cilium basal body. Early endosome.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Interacts with GRAP2 and GRB2. Interacts with UBAP1. Interacts with CHMP4B.

Family&Domains:

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

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