OIP5 Antibody - #DF12217
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12217, RRID:AB_2845022.
Fold/Unfold
5730547N13Rik; Cancer/testis antigen 86; CT 86; CT86; hMIS18beta; LAP2alpha interactor 25; LINT 25; LINT25; MIS18B; MIS18beta; MS18B_HUMAN; OIP 5; OIP-5; OIP5; Opa interacting protein 5; Opa-interacting protein 5; Protein Mis18-beta;
Immunogens
- O43482 MS18B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAQPLRHRSRCATPPRGDFCGGTERAIDQASFTTSMEWDTQVVKGSSPLGPAGLGAEEPAAGPQLPSWLQPERCAVFQCAQCHAVLADSVHLAWDLSRSLGAVVFSRVTNNVVLEAPFLVGIEGSLKGSTYNLLFCGSCGIPVGFHLYSTHAALAALRGHFCLSSDKMVCYLLKTKAIVNASEMDIQNVPLSEKIAELKEKIVLTHNRLKSLMKILSEVTPDQSKPEN
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O43482 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R7 | Methylation | Uniprot | |
| T14 | Phosphorylation | Uniprot | |
| S47 | Phosphorylation | Uniprot | |
| S48 | Phosphorylation | Uniprot | |
| K175 | Ubiquitination | Uniprot | |
| K195 | Ubiquitination | Uniprot | |
| K202 | Ubiquitination | Uniprot | |
| S212 | Phosphorylation | Uniprot | |
| K215 | Methylation | Uniprot | |
| K215 | Ubiquitination | Uniprot | |
| S218 | Phosphorylation | Uniprot | |
| T221 | Phosphorylation | Uniprot | |
| S225 | Phosphorylation | Uniprot | |
| K226 | Methylation | Uniprot | |
| K226 | Ubiquitination | Uniprot |
Research Backgrounds
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
Nucleus. Chromosome. Chromosome>Centromere.
Note: Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin.
Homodimer, and heterodimer with MIS18A. Identified in a complex containing MIS18A, OIP5/MIS18B, MIS18BP1, RBBP7 and RBBP4. Binds outer membrane protein OpaP from Neisseria gonorrhoeae (in vitro).
Belongs to the mis18 family.
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