FAM96B Antibody - #DF12272
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12272, RRID:AB_2845077.
Fold/Unfold
CGI 128; FAM96B; Family with sequence similarity 96, member B; HSPC118; Hypothetical protein LOC51647; MIP18; MIP18_HUMAN; Mitotic spindle-associated MMXD complex subunit MIP18; MSS19-interacting protein of 18 kDa; Protein FAM96B;
Immunogens
- Q9Y3D0 CIA2B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVGGGGVGGGLLENANPLIYQRSGERPVTAGEEDEQVPDSIDAREIFDLIRSINDPEHPLTLEELNVVEQVRVQVSDPESTVAVAFTPTIPHCSMATLIGLSIKVKLLRSLPQRFKMDVHITPGTHASEHAVNKQLADKERVAAALENTHLLEVVNQCLSARS
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9Y3D0 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y20 | Phosphorylation | Uniprot | |
| T29 | Phosphorylation | Uniprot | |
| K116 | Ubiquitination | Uniprot | |
| K134 | Ubiquitination | Uniprot | |
| K139 | Ubiquitination | Uniprot | |
| S163 | Phosphorylation | Uniprot |
Research Backgrounds
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD.
Nucleus. Cytoplasm>Cytoskeleton>Spindle.
Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, CIAO2B, MMS19 and SLC25A5. Interacts with CIAO1, ERCC2 and MMS19; the interactions are direct.
Belongs to the MIP18 family.
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