HPS5 Antibody - #DF12281
| Product: | HPS5 Antibody |
| Catalog: | DF12281 |
| Description: | Rabbit polyclonal antibody to HPS5 |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 135-141 kDa; 127kD(Calculated). |
| Uniprot: | Q9UPZ3 |
| RRID: | AB_2845086 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12281, RRID:AB_2845086.
Fold/Unfold
AIBP63; Alpha integrin binding protein 63; BLOC2S2; Hermansky Pudlak syndrome 5 protein; HPS5, biogenesis of lysosomal organelles complex 2 subunit 2; Ru2; Ruby eye protein 2 homolog;
Immunogens
Widely expressed. Isoform 1:Highly expressed in lungs and testis. Isoform 2:Highly expressed in placenta, kidney, testis ovary, lung and thymus.
- Q9UPZ3 HPS5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAFVPVIPESYSHVLAEFESLDPLLSALRLDSSRLKCTSIAVSRKWLALGSSGGGLHLIQKEGWKHRLFLSHREGAISQVACCLHDDDYVAVATSQGLVVVWELNQERRGKPEQMYVSSEHKGRRVTALCWDTAILRVFVGDHAGKVSAIKLNTSKQAKAAAAFVMFPVQTITTVDSCVVQLDYLDGRLLISSLTRSFLCDTEREKFWKIGNKERDGEYGACFFPGRCSGGQQPLIYCARPGSRMWEVNFDGEVISTHQFKKLLSLPPLPVITLRSEPQYDHTAGSSQSLSFPKLLHLSEHCVLTWTERGIYIFIPQNVQVLLWSEVKDIQDVAVCRNELFCLHLNGKVSHLSLISVERCVERLLRRGLWNLAARTCCLFQNSVIASRARKTLTADKLEHLKSQLDHGTYNDLISQLEELILKFEPLDSACSSRRSSISSHESFSILDSGIYRIISSRRGSQSDEDSCSLHSQTLSEDERFKEFTSQQEEDLPDQCCGSHGNEDNVSHAPVMFETDKNETFLPFGIPLPFRSPSPLVSLQAVKESVSSFVRKTTEKIGTLHTSPDLKVRPELRGDEQSCEEDVSSDTCPKEEDTEEEKEVTSPPPEEDRFQELKVATAEAMTKLQDPLVLFESESLRMVLQEWLSHLEKTFAMKDFSGVSDTDNSSMKLNQDVLLVNESKKGILDEDNEKEKRDSLGNEESVDKTACECVRSPRESLDDLFQICSPCAIASGLRNDLAELTTLCLELNVLNSKIKSTSGHVDHTLQQYSPEILACQFLKKYFFLLNLKRAKESIKLSYSNSPSVWDTFIEGLKEMASSNPVYMEMEKGDLPTRLKLLDDEVPFDSPLLVVYATRLYEKFGESALRSLIKFFPSILPSDIIQLCHHHPAEFLAYLDSLVKSRPEDQRSSFLESLLQPESLRLDWLLLAVSLDAPPSTSTMDDEGYPRPHSHLLSWGYSQLILHLIKLPADFITKEKMTDICRSCGFWPGYLILCLELERRREAFTNIVYLNDMSLMEGDNGWIPETVEEWKLLLHLIQSKSTRPAPQESLNGSLSDGPSPINVENVALLLAKAMGPDRAWSLLQECGLALELSEKFTRTCDILRIAEKRQRALIQSMLEKCDRFLWSQQA
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9UPZ3 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K36 | Ubiquitination | Uniprot | |
| S118 | Phosphorylation | Uniprot | |
| K151 | Ubiquitination | Uniprot | |
| K209 | Ubiquitination | Uniprot | |
| Y219 | Phosphorylation | Uniprot | |
| S229 | Phosphorylation | Uniprot | |
| K262 | Ubiquitination | Uniprot | |
| S265 | Phosphorylation | Uniprot | |
| T273 | Phosphorylation | Uniprot | |
| K391 | Ubiquitination | Uniprot | |
| K397 | Ubiquitination | Uniprot | |
| K402 | Ubiquitination | Uniprot | |
| S429 | Phosphorylation | Uniprot | |
| S437 | Phosphorylation | Uniprot | |
| S439 | Phosphorylation | Uniprot | |
| S443 | Phosphorylation | Uniprot | |
| S449 | Phosphorylation | Uniprot | |
| Y452 | Phosphorylation | Uniprot | |
| S461 | Phosphorylation | Uniprot | |
| S463 | Phosphorylation | Uniprot | |
| S469 | Phosphorylation | Uniprot | |
| S532 | Phosphorylation | Uniprot | |
| S534 | Phosphorylation | Uniprot | |
| K543 | Ubiquitination | Uniprot | |
| K556 | Ubiquitination | Uniprot | |
| T562 | Phosphorylation | Uniprot | |
| S563 | Phosphorylation | Uniprot | |
| K567 | Ubiquitination | Uniprot | |
| S578 | Phosphorylation | Uniprot | |
| S585 | Phosphorylation | Uniprot | |
| T594 | Phosphorylation | Uniprot | |
| S602 | Phosphorylation | Uniprot | |
| K614 | Ubiquitination | Uniprot | |
| K623 | Ubiquitination | Uniprot | |
| K654 | Ubiquitination | Uniprot | |
| S660 | Phosphorylation | Uniprot | |
| S679 | Phosphorylation | Uniprot | |
| K680 | Ubiquitination | Uniprot | |
| S695 | Phosphorylation | Uniprot | |
| S701 | Phosphorylation | Uniprot | |
| K704 | Ubiquitination | Uniprot | |
| S712 | Phosphorylation | Uniprot | |
| S725 | Phosphorylation | Uniprot | |
| Y781 | Phosphorylation | Uniprot | |
| Y822 | Phosphorylation | Uniprot | |
| K835 | Ubiquitination | Uniprot | |
| K858 | Ubiquitination | Uniprot | |
| S1052 | Phosphorylation | Uniprot | |
| S1080 | Phosphorylation | Uniprot | |
| K1119 | Ubiquitination | Uniprot |
Research Backgrounds
May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins.
Cytoplasm>Cytosol.
Widely expressed. Isoform 1:Highly expressed in lungs and testis. Isoform 2:Highly expressed in placenta, kidney, testis ovary, lung and thymus.
Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6. Interacts with HPS6. Interacts with HPS3. May interact with all alpha-integrin chains that have an aromatic residue before the first lysine of the conserved KXGFFKR motif, including ITGA2, ITGA3, ITGA5 and ITGA6.
Belongs to the HPS5 family.
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