HRP2 Antibody - #DF12282

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Product: HRP2 Antibody
Catalog: DF12282
Description: Rabbit polyclonal antibody to HRP2
Application: WB IHC
Reactivity: Human, Mouse, Rat, Monkey
Prediction: Pig, Sheep, Dog, Xenopus
Mol.Wt.: 74 kDa; 74kD(Calculated).
Uniprot: Q7Z4V5
RRID: AB_2845087

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat,Monkey
Prediction:
Pig(100%), Sheep(100%), Dog(100%), Xenopus(91%)
Clonality:
Polyclonal
Specificity:
HRP2 Antibody detects endogenous levels of total HRP2.
RRID:
AB_2845087
Cite Format: Affinity Biosciences Cat# DF12282, RRID:AB_2845087.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

HDGF-2; HDGF2; Hdgfrp2; HDGR2_HUMAN; Hepatoma-derived growth factor 2; Hepatoma-derived growth factor; Hepatoma-derived growth factor-related protein 2; heptoma derived growth factor related protein 2; HRP-2;

Immunogens

Immunogen:
Uniprot:

Q7Z4V5(HDGR2_HUMAN) >>Visit HPA database.

Gene(ID):
HDGFL2(84717)
Expression:
Q7Z4V5 HDGR2_HUMAN:

Widely expressed. High expression is found in heart, skeletal muscle, ovary and testis. Overexpression is frequently observed in hepatocellular carcinoma samples.

Sequence:
MPHAFKPGDLVFAKMKGYPHWPARIDDIADGAVKPPPNKYPIFFFGTHETAFLGPKDLFPYDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPPPVSSSDSEAPEANPADGSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHDSVREGPDLDRPGSDRQERERARGDSEALDEES

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Sheep
100
Dog
100
Xenopus
91
Zebrafish
45
Horse
0
Bovine
0
Chicken
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q7Z4V5 As Substrate

Site PTM Type Enzyme
K16 Ubiquitination
Y18 Phosphorylation
K34 Acetylation
K34 Ubiquitination
K39 Acetylation
Y61 Phosphorylation
K63 Acetylation
K63 Ubiquitination
K65 Ubiquitination
K70 Ubiquitination
K73 Ubiquitination
S114 Phosphorylation
S137 Phosphorylation
S142 Phosphorylation
S144 Phosphorylation
S146 Phosphorylation
S149 Phosphorylation
S150 Phosphorylation
S153 Phosphorylation
T159 Phosphorylation
K163 Methylation
S165 Phosphorylation
K168 Methylation
S174 Phosphorylation
S175 Phosphorylation
S194 Phosphorylation
S200 Phosphorylation
T205 Phosphorylation
S230 Phosphorylation
S232 Phosphorylation
S234 Phosphorylation
S236 Phosphorylation
S240 Phosphorylation
S253 Phosphorylation
S255 Phosphorylation
S256 Phosphorylation
S257 Phosphorylation
S258 Phosphorylation
S259 Phosphorylation
S260 Phosphorylation
S261 Phosphorylation
S264 Phosphorylation
S266 Phosphorylation
S303 Phosphorylation
S305 Phosphorylation
S366 Phosphorylation
S369 Phosphorylation
S370 Phosphorylation
K383 Methylation
S395 Phosphorylation
S396 Phosphorylation
S397 Phosphorylation
S399 Phosphorylation
S412 Phosphorylation
S454 Phosphorylation
S458 Phosphorylation
K477 Ubiquitination
K487 Ubiquitination
S490 Phosphorylation
K494 Ubiquitination
K524 Acetylation
K524 Ubiquitination
K538 Ubiquitination
K554 Acetylation
K554 Ubiquitination
K560 Acetylation
K574 Ubiquitination
S599 Phosphorylation
S608 Phosphorylation
S613 Phosphorylation
S625 Phosphorylation
C631 S-Nitrosylation
S633 Phosphorylation
S634 Phosphorylation
S640 Phosphorylation
S652 Phosphorylation
S664 Phosphorylation
S671 Phosphorylation

Research Backgrounds

Function:

Involved in cellular growth control, through the regulation of cyclin D1 expression.

Subcellular Location:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Widely expressed. High expression is found in heart, skeletal muscle, ovary and testis. Overexpression is frequently observed in hepatocellular carcinoma samples.

Subunit Structure:

Interacts with HDGF (By similarity). Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3). Interacts with trimethylated 'Lys-79' of histone H3 (H3K79me3), but has higher affinity for H3K36me3. Interacts with IWS1.

Family&Domains:

Belongs to the HDGF family.

Restrictive clause

 

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