STBD1 Antibody - #DF12326

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Product: STBD1 Antibody
Catalog: DF12326
Description: Rabbit polyclonal antibody to STBD1
Application: WB IHC IF/ICC
Reactivity: Human, Mouse
Mol.Wt.: 35-43 kDa; 39kD(Calculated).
Uniprot: O95210
RRID: AB_2845131

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 100ul $280 In stock
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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Clonality:
Polyclonal
Specificity:
STBD1 Antibody detects endogenous levels of total STBD1.
RRID:
AB_2845131
Cite Format: Affinity Biosciences Cat# DF12326, RRID:AB_2845131.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

FLJ41801; Genethonin-1; Genethonin1; GENEX 3414; GENEX3414; GENX 3414; GENX3414; Starch binding domain 1; Starch binding domain containing protein 1; Starch-binding domain-containing protein 1; STBD 1; STBD1; STBD1_HUMAN;

Immunogens

Immunogen:
Uniprot:

O95210(STBD1_HUMAN) >>Visit HPA database.

Gene(ID):
STBD1(8987)
Expression:
O95210 STBD1_HUMAN:

Expressed at high level in skeletal and cardiac muscles. Moderately expressed in liver and placenta. No expression is found in pancreas, kidney or lung. Present in skeletal muscle, heart and placenta (at protein level).

Sequence:
MGAVWSALLVGGGLAGALFVWLLRGGPGDTGKDGDAEQEKDAPLGGAAIPGGHQSGSSGLSPGPSGQELVTKPEHLQESNGHLISKTKDLGKLQAASWRLQNPSREVCDNSREHVPSGQFPDTEAPATSETSNSRSYSEVSRNESLESPMGEWGFQKGQEISAKAATCFAEKLPSSNLLKNRAKEEMSLSDLNSQDRVDHEEWEMVPRHSSWGDVGVGGSLKAPVLNLNQGMDNGRSTLVEARGQQVHGKMERVAVMPAGSQQVSVRFQVHYVTSTDVQFIAVTGDHECLGRWNTYIPLHYNKDGFWSHSIFLPADTVVEWKFVLVENGGVTRWEECSNRFLETGHEDKVVHAWWGIH

PTMs - O95210 As Substrate

Site PTM Type Enzyme
S6 Phosphorylation
S57 Phosphorylation
S65 Phosphorylation
S79 Phosphorylation
S85 Phosphorylation
S97 Phosphorylation
S117 Phosphorylation
S136 Phosphorylation
S138 Phosphorylation
S141 Phosphorylation
S145 Phosphorylation
S148 Phosphorylation
S175 Phosphorylation
S176 Phosphorylation
S188 Phosphorylation
S190 Phosphorylation
S194 Phosphorylation
S210 Phosphorylation
S211 Phosphorylation
S220 Phosphorylation

Research Backgrounds

Function:

Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes.

PTMs:

Ubiquitinated, which leads to proteasomal degradation.

Subcellular Location:

Preautophagosomal structure membrane>Single-pass type III membrane protein. Endoplasmic reticulum membrane>Single-pass type III membrane protein. Cell membrane>Sarcolemma>T-tubule.
Note: Also detected near the junctional sarcoplasmic reticulum (PubMed:9794794). Concentrates at perinuclear structures (PubMed:21893048).

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed at high level in skeletal and cardiac muscles. Moderately expressed in liver and placenta. No expression is found in pancreas, kidney or lung. Present in skeletal muscle, heart and placenta (at protein level).

Subunit Structure:

Interacts with the ATG8 family proteins GABARAP and GABARAPL1. Interacts with several glycogen-associated proteins, such as GYS2 (liver glycogen synthase), GDE (glycogen debranching enzyme), GBE1 (glycogen branching enzyme 1) and EPM2A (Laforin).

Family&Domains:

The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family protein GABARAPL1.

The C-terminal CBM20 domain is required for the interaction with glycogen and glycogen-associated proteins.

References

1). D-pinitol alleviates diabetic cardiomyopathy by inhibiting the optineurin-mediated endoplasmic reticulum stress and glycophagy signaling pathway. Phytotherapy research : PTR, 2024 (PubMed: 38311336) [IF=6.1]

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