CCDC93 Antibody - #DF12362
| Product: | CCDC93 Antibody |
| Catalog: | DF12362 |
| Description: | Rabbit polyclonal antibody to CCDC93 |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Zebrafish, Bovine, Sheep, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 73 kDa; 73kD(Calculated). |
| Uniprot: | Q567U6 |
| RRID: | AB_2845167 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12362, RRID:AB_2845167.
Fold/Unfold
CCD93_HUMAN; CCDC93; Coiled-coil domain containing 93; Coiled-coil domain-containing protein 93; FLJ10996; FLJ25197; MGC13033;
Immunogens
- Q567U6 CCD93_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGLPRGPEGQGLPEVETREDEEQNVKLTEILELLVAAGYFRARIKGLSPFDKVVGGMTWCITTCNFDVDVDLLFQENSTIGQKIALSEKIVSVLPRMKCPHQLEPHQIQGMDFIHIFPVVQWLVKRAIETKEEMGDYIRSYSVSQFQKTYSLPEDDDFIKRKEKAIKTVVDLSEVYKPRRKYKRHQGAEELLDEESRIHATLLEYGRRYGFSRQSKMEKAEDKKTALPAGLSATEKADAHEEDELRAAEEQRIQSLMTKMTAMANEESRLTASSVGQIVGLCSAEIKQIVSEYAEKQSELSAEESPEKLGTSQLHRRKVISLNKQIAQKTKHLEELRASHTSLQARYNEAKKTLTELKTYSEKLDKEQAALEKIESKADPSILQNLRALVAMNENLKSQEQEFKAHCREEMTRLQQEIENLKAERAPRGDEKTLSSGEPPGTLTSAMTHDEDLDRRYNMEKEKLYKIRLLQARRNREIAILHRKIDEVPSRAELIQYQKRFIELYRQISAVHKETKQFFTLYNTLDDKKVYLEKEISLLNSIHENFSQAMASPAARDQFLRQMEQIVEGIKQSRMKMEKKKQENKMRRDQLNDQYLELLEKQRLYFKTVKEFKEEGRKNEMLLSKVKAKAS
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q567U6 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K45 | Ubiquitination | Uniprot | |
| K89 | Ubiquitination | Uniprot | |
| K131 | Ubiquitination | Uniprot | |
| Y137 | Phosphorylation | Uniprot | |
| K148 | Ubiquitination | Uniprot | |
| S151 | Phosphorylation | Uniprot | |
| K160 | Ubiquitination | Uniprot | |
| S173 | Phosphorylation | Uniprot | |
| Y176 | Phosphorylation | Uniprot | |
| K177 | Ubiquitination | Uniprot | |
| Y209 | Phosphorylation | Uniprot | |
| K224 | Ubiquitination | Uniprot | |
| K236 | Ubiquitination | Uniprot | |
| S255 | Phosphorylation | Uniprot | |
| K259 | Ubiquitination | Uniprot | |
| T261 | Phosphorylation | Uniprot | |
| S268 | Phosphorylation | Uniprot | |
| S274 | Phosphorylation | Uniprot | |
| K287 | Ubiquitination | Uniprot | |
| K296 | Ubiquitination | Uniprot | |
| S298 | Phosphorylation | Uniprot | |
| S301 | Phosphorylation | Uniprot | |
| S305 | Phosphorylation | Uniprot | |
| K308 | Ubiquitination | Uniprot | |
| S312 | Phosphorylation | Uniprot | |
| K318 | Ubiquitination | Uniprot | |
| S321 | Phosphorylation | Uniprot | |
| K324 | Ubiquitination | Uniprot | |
| Y347 | Phosphorylation | Uniprot | |
| K351 | Acetylation | Uniprot | |
| K352 | Acetylation | Uniprot | |
| T355 | Phosphorylation | Uniprot | |
| K358 | Acetylation | Uniprot | |
| Y360 | Phosphorylation | Uniprot | |
| K363 | Ubiquitination | Uniprot | |
| K377 | Ubiquitination | Uniprot | |
| K397 | Ubiquitination | Uniprot | |
| K404 | Ubiquitination | Uniprot | |
| K422 | Ubiquitination | Uniprot | |
| T433 | Phosphorylation | Uniprot | |
| K484 | Ubiquitination | Uniprot | |
| K499 | Ubiquitination | Uniprot | |
| K571 | Ubiquitination | Uniprot | |
| S573 | Phosphorylation | Uniprot | |
| K601 | Ubiquitination | Uniprot | |
| K625 | Ubiquitination | Uniprot |
Research Backgrounds
Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2C.
(Microbial infection) The CCC complex, in collaboration with the heterotrimeric retriever complex, mediates the exit of human papillomavirus to the cell surface.
Early endosome.
Interacts with COMMD1, COMMD2 COMMD3, COMMD4, COMMD5, COMMD6, COMMD7, COMMD8, COMMD9, COMMD10, WASHC1. Interacts directly with WASHC2C. Interacts with CCDC93; proposed to be a component of the CCC (COMMD/CCDC22/CCDC93) complex which contains at least COMMD1 (and possibly other COMM domain-containing proteins), CCDC22 and CCDC93; in the complex interacts directly with CCDC22 (Probable). Interacts with VPS35L; associates with the retriever complex. Interacts with SNX17 and SNX31.
Belongs to the CCDC93 family.
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