LIV-1/ZIP6 Antibody - #DF12420

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Product: LIV-1/ZIP6 Antibody
Catalog: DF12420
Description: Rabbit polyclonal antibody to LIV-1/ZIP6
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
Mol.Wt.: 100 kDa; 85kD(Calculated).
Uniprot: Q13433
RRID: AB_2845225

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Zebrafish(90%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(80%), Xenopus(80%)
Clonality:
Polyclonal
Specificity:
LIV-1/ZIP6 Antibody detects endogenous levels of total LIV-1/ZIP6.
RRID:
AB_2845225
Cite Format: Affinity Biosciences Cat# DF12420, RRID:AB_2845225.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Estrogen regulated protein LIV 1 6; Estrogen-regulated protein LIV-1; LIV 1; LIV 1 protein, estrogen regulated; S39A6_HUMAN; SLC39A6; Solute carrier family 39 (metal ion transporter), member 6; solute carrier family 39 (zinc transporter), member 6; Solute carrier family 39 member 6; Zinc transporter ZIP6; ZIP 6; ZIP-6; Zrt and Irt like protein 6; Zrt- and Irt-like protein 6;

Immunogens

Immunogen:
Uniprot:

Q13433(S39A6_HUMAN) >>Visit HPA database.

Gene(ID):
SLC39A6(25800)
Expression:
Q13433 S39A6_HUMAN:

Highly expressed in the breast, prostate, placenta, kidney, pituitary and corpus callosum. Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the cervix and lung carcinoma.

Sequence:
MARKLSVILILTFALSVTNPLHELKAAAFPQTTEKISPNWESGINVDLAISTRQYHLQQLFYRYGENNSLSVEGFRKLLQNIGIDKIKRIHIHHDHDHHSDHEHHSDHERHSDHEHHSEHEHHSDHDHHSHHNHAASGKNKRKALCPDHDSDSSGKDPRNSQGKGAHRPEHASGRRNVKDSVSASEVTSTVYNTVSEGTHFLETIETPRPGKLFPKDVSSSTPPSVTSKSRVSRLAGRKTNESVSEPRKGFMYSRNTNENPQECFNASKLLTSHGMGIQVPLNATEFNYLCPAIINQIDARSCLIHTSEKKAEIPPKTYSLQIAWVGGFIAISIISFLSLLGVILVPLMNRVFFKFLLSFLVALAVGTLSGDAFLHLLPHSHASHHHSHSHEEPAMEMKRGPLFSHLSSQNIEESAYFDSTWKGLTALGGLYFMFLVEHVLTLIKQFKDKKKKNQKKPENDDDVEIKKQLSKYESQLSTNEEKVDTDDRTEGYLRADSQEPSHFDSQQPAVLEEEEVMIAHAHPQEVYNEYVPRGCKNKCHSHFHDTLGQSDDLIHHHHDYHHILHHHHHQNHHPHSHSQRYSREELKDAGVATLAWMVIMGDGLHNFSDGLAIGAAFTEGLSSGLSTSVAVFCHELPHELGDFAVLLKAGMTVKQAVLYNALSAMLAYLGMATGIFIGHYAENVSMWIFALTAGLFMYVALVDMVPEMLHNDASDHGCSRWGYFFLQNAGMLLGFGIMLLISIFEHKIVFRINF

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Zebrafish
90
Xenopus
80
Chicken
80
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q13433 As Substrate

Site PTM Type Enzyme
N67 N-Glycosylation
S71 Phosphorylation
K77 Ubiquitination
K86 Ubiquitination
K143 Ubiquitination
S189 Phosphorylation
Y192 Phosphorylation
S196 O-Glycosylation
K212 Ubiquitination
S219 O-Glycosylation
S221 O-Glycosylation
T222 O-Glycosylation
S225 O-Glycosylation
T227 O-Glycosylation
S228 O-Glycosylation
K229 Ubiquitination
N241 N-Glycosylation
K249 Ubiquitination
K310 Ubiquitination
S409 Phosphorylation
K456 Ubiquitination
K457 Ubiquitination
K467 Ubiquitination
K468 Ubiquitination
S471 Phosphorylation
K472 Ubiquitination
Y473 Phosphorylation
S475 Phosphorylation
S478 Phosphorylation
T479 Phosphorylation
K483 Ubiquitination
T486 Phosphorylation
T490 Phosphorylation
Y493 Phosphorylation
Y528 Phosphorylation
Y531 Phosphorylation
S583 Phosphorylation

Research Backgrounds

Function:

May act as a zinc-influx transporter.

PTMs:

N-glycosylated.

Subcellular Location:

Cell membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Highly expressed in the breast, prostate, placenta, kidney, pituitary and corpus callosum. Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the cervix and lung carcinoma.

Family&Domains:

Belongs to the ZIP transporter (TC 2.A.5) family.

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