PACS2 Antibody - #DF12441

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Product: PACS2 Antibody
Catalog: DF12441
Description: Rabbit polyclonal antibody to PACS2
Application: WB IHC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Rabbit, Dog
Mol.Wt.: 116 kDa; 98kD(Calculated).
Uniprot: Q86VP3
RRID: AB_2845246

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Bovine(100%), Horse(100%), Rabbit(100%), Dog(100%)
Clonality:
Polyclonal
Specificity:
PACS2 Antibody detects endogenous levels of total PACS2.
RRID:
AB_2845246
Cite Format: Affinity Biosciences Cat# DF12441, RRID:AB_2845246.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

6720425G15Rik; AW208651; AW489976; E230011J22; FLJ25488; KIAA0602; mKIAA0602; PACS 2; PACS-2; PACS1 like protein; PACS1-like protein; PACS1L; PACS2; PACS2_HUMAN; Phosphofurin acidic cluster sorting protein 1 like; Phosphofurin acidic cluster sorting protein 2;

Immunogens

Immunogen:
Uniprot:

Q86VP3(PACS2_HUMAN) >>Visit HPA database.

Gene(ID):
PACS2(23241)
Expression:
Q86VP3 PACS2_HUMAN:

Broadly expressed, with greatest levels in skeletal muscle followed by heart, brain, pancreas and testis.

Sequence:
MAERGRLGLPGAPGALNTPVPMNLFATWEVDGSSPSCVPRLCSLTLKKLVVFKELEKELISVVIAVKMQGSKRILRSHEIVLPPSGQVETDLALTFSLQYPHFLKREGNKLQIMLQRRKRYKNRTILGYKTLAAGSISMAEVMQHPSEGGQVLSLCSSIKEAPVKAAEIWIASLSSQPIDHEDSTMQAGPKAKSTDNYSEEEYESFSSEQEASDDAVQGQDLDEDDFDVGKPKKQRRSIVRTTSMTRQQNFKQKVVALLRRFKVSDEVLDSEQDPAEHIPEAEEDLDLLYDTLDMEHPSDSGPDMEDDDSVLSTPKPKLRPYFEGLSHSSSQTEIGSIHSARSHKEPPSPADVPEKTRSLGGRQPSDSVSDTVALGVPGPREHPGQPEDSPEAEASTLDVFTERLPPSGRITKTESLVIPSTRSEGKQAGRRGRSTSLKERQAARPQNERANSLDNERCPDARSQLQIPRKTVYDQLNHILISDDQLPENIILVNTSDWQGQFLSDVLQRHTLPVVCTCSPADVQAAFSTIVSRIQRYCNCNSQPPTPVKIAVAGAQHYLSAILRLFVEQLSHKTPDWLGYMRFLVIPLGSHPVARYLGSVDYRYNNFFQDLAWRDLFNKLEAQSAVQDTPDIVSRITQYIAGANCAHQLPIAEAMLTYKQKSPDEESSQKFIPFVGVVKVGIVEPSSATSGDSDDAAPSGSGTLSSTPPSASPAAKEASPTPPSSPSVSGGLSSPSQGVGAELMGLQVDYWTAAQPADRKRDAEKKDLPVTKNTLKCTFRSLQVSRLPSSGEAAATPTMSMTVVTKEKNKKVMFLPKKAKDKDVESKSQCIEGISRLICTARQQQNMLRVLIDGVECSDVKFFQLAAQWSSHVKHFPICIFGHSKATF

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Dog
100
Rabbit
100
Sheep
0
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q86VP3 As Substrate

Site PTM Type Enzyme
S43 Phosphorylation
S184 Phosphorylation
T185 Phosphorylation
S238 Phosphorylation
S244 Phosphorylation
T246 Phosphorylation
S329 Phosphorylation
S330 Phosphorylation
S331 Phosphorylation
T333 Phosphorylation
S343 Phosphorylation
S349 Phosphorylation
S366 Phosphorylation
S368 Phosphorylation
S390 Phosphorylation
T414 Phosphorylation
S416 Phosphorylation
T436 Phosphorylation
S437 Phosphorylation P31749 (AKT1)
S453 Phosphorylation
S691 Phosphorylation
T722 Phosphorylation
K766 Acetylation
K767 Acetylation
K773 Acetylation
K777 Acetylation
T806 Phosphorylation

Research Backgrounds

Function:

Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.

Subcellular Location:

Endoplasmic reticulum. Mitochondrion.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Broadly expressed, with greatest levels in skeletal muscle followed by heart, brain, pancreas and testis.

Subunit Structure:

Interacts with BID and PKD2. Interacts with SIRT1. Interacts with HDAC1. Interacts with TRPV1.

(Microbial infection) Interacts with HIV-1 Nef.

Family&Domains:

Belongs to the PACS family.

References

1). GRP75-dependent mitochondria-ER contacts ensure cell survival during early mouse thymocyte development. Developmental cell, 2024 (PubMed: 38981469) [IF=10.7]

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